L
LiPing Liu
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 27
Citations - 4827
LiPing Liu is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Chemokine receptor. The author has an hindex of 20, co-authored 26 publications receiving 3971 citations. Previous affiliations of LiPing Liu include Cleveland Clinic.
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Journal ArticleDOI
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Oleg Butovsky,Mark P. Jedrychowski,Craig S. Moore,Ron Cialic,Amanda J. Lanser,Galina Gabriely,Thomas Koeglsperger,Ben Dake,Pauline M. Wu,Camille Doykan,Zain Fanek,LiPing Liu,Zhuoxun Chen,Jeffrey D. Rothstein,Richard M. Ransohoff,Steven P. Gygi,Jack P. Antel,Howard L. Weiner +17 more
TL;DR: It is found that TGF-β was required for the in vitro development of microglia that express the microglial molecular signature characteristic of adultmicroglia and that microglian were absent in the CNS of TGF -β1–deficient mice.
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Differential roles of microglia and monocytes in the inflamed central nervous system.
Ryo Yamasaki,Haiyan Lu,Oleg Butovsky,Nobuhiko Ohno,Anna Rietsch,Ron Cialic,Pauline M. Wu,Camille Doykan,Jessica Lin,Anne C. Cotleur,Grahame J. Kidd,Musab M. Zorlu,Nathan Sun,Weiwei Hu,LiPing Liu,Jar Chi Lee,Sarah E. Taylor,Lindsey Uehlein,Lindsey Uehlein,Debra Dixon,Jinyu Gu,Crina M. Floruta,Min Zhu,Israel F. Charo,Howard L. Weiner,Richard M. Ransohoff +25 more
TL;DR: Phagocytic monocyte-derived macrophages associate with the nodes of Ranvier and initiate demyelination while microglia clear debris and display a suppressed metabolic gene signature in EAE.
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Erratum: Identification of a unique TGF-β-dependent molecular and functional signature in microglia (Nature Neuroscience (2014) 17 (131-143))
Oleg Butovsky,Mark P. Jedrychowski,Craig S. Moore,Ron Cialic,Amanda J. Lanser,Galina Gabriely,Thomas Koeglsperger,Ben Dake,Pauline M. Wu,Camille Doykan,Zain Fanek,LiPing Liu,Zhuoxun Chen,Jeffrey D. Rothstein,Richard M. Ransohoff,Steven P. Gygi,Jack P. Antel,Howard L. Weiner +17 more
TL;DR: Corrigendum: Identification of a unique TGF-β–dependent molecular and functional signature in microglia and its role in cell reprograming is identified.
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Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis
Zizhen Kang,Cengiz Z. Altuntas,Muhammet F. Gulen,Caini Liu,Natalia Giltiay,Hongwei Qin,LiPing Liu,Wen Qian,Richard M. Ransohoff,Cornelia C. Bergmann,Stephen A. Stohlman,Vincent K. Tuohy,Xiaoxia Li +12 more
TL;DR: Astroctyes are critical in IL-17-Act1-mediated leukocyte recruitment during autoimmune-induced inflammation of the CNS, and targeted Act1 deficiency in neuroectoderm-derived CNS-resident cells resulted in markedly reduced severity in EAE.
Journal ArticleDOI
CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis
LiPing Liu,Abdelmadjid Belkadi,Lindsey Darnall,Taofang Hu,Caitlin Drescher,Anne C. Cotleur,Dolly Ann Padovani-Claudio,Tao He,Karen Choi,Thomas E. Lane,Robert H. Miller,Richard M. Ransohoff +11 more
TL;DR: A two-hit process of cuprizone-induced demyelination is supported, supporting the idea that multiple sclerosis pathogenesis features extensive oligodendrocyte cell loss.