P
Pei-San Tsai
Researcher at University of Colorado Boulder
Publications - 63
Citations - 2098
Pei-San Tsai is an academic researcher from University of Colorado Boulder. The author has contributed to research in topics: Gonadotropin-releasing hormone & Fibroblast growth factor. The author has an hindex of 25, co-authored 62 publications receiving 1970 citations. Previous affiliations of Pei-San Tsai include University of California, Los Angeles & University of California, Berkeley.
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Journal ArticleDOI
Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 Are Identified in Individuals with Congenital Hypogonadotropic Hypogonadism
Hichem Miraoui,Andrew A. Dwyer,Andrew A. Dwyer,Gerasimos P. Sykiotis,Gerasimos P. Sykiotis,Lacey Plummer,Wilson C. J. Chung,Bihua Feng,Andrew Beenken,Jeffrey A Clarke,Tune H. Pers,Tune H. Pers,Tune H. Pers,Piotr Dworzynski,Kimberley Keefe,Marek Niedziela,Taneli Raivio,William F. Crowley,Stephanie B. Seminara,Richard Quinton,Virginia A. Hughes,Virginia A. Hughes,Philip Kumanov,Jacques Young,Maria A Yialamas,Janet E. Hall,Guy Van Vliet,Jean-Pierre Chanoine,John L.R. Rubenstein,Moosa Mohammadi,Pei-San Tsai,Yisrael Sidis,Yisrael Sidis,Kasper Lage,Nelly Pitteloud,Nelly Pitteloud +35 more
TL;DR: It is hypothesized that mutations in genes encoding a broader range of modulators of the FGFR1 pathway might contribute to the genetics of CHH as causal or modifier mutations and validate the ability of a bioinformatics algorithm on the basis of protein-protein interactome data (interactome-based affiliation scoring [IBAS]) to identify high-quality candidate genes.
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Fibroblast growth factor 8 signaling through fibroblast growth factor receptor 1 is required for the emergence of gonadotropin-releasing hormone neurons.
TL;DR: The results show that the early emergence of GnRH neurons from the embryonic olfactory placode requires FGF8 signaling, which is mediated through FGFR1, not FGFR3, which provides compelling evidence that the developing GnRH system is exquisitely sensitive to reduced levels of FGF signaling.
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Novel FGF8 Mutations Associated with Recessive Holoprosencephaly, Craniofacial Defects, and Hypothalamo-Pituitary Dysfunction
Mark J. McCabe,Carles Gaston-Massuet,Vaitsa Tziaferi,Louise C. Gregory,Kyriaki S. Alatzoglou,Massimo Signore,Eduardo Puelles,Dianne Gerrelli,I. Sadaf Farooqi,Jamal Raza,Joanna Walker,Scott I. Kavanaugh,Pei-San Tsai,Nelly Pitteloud,Juan Pedro Martinez-Barbera,Mehul T. Dattani +15 more
TL;DR: FGF8 is implicate in the etiology of recessive HPE and potentially septo-optic dysplasia/Moebius syndrome for the first time to the authors' knowledge and is important for the development of the ventral diencephalon, hypothalamus, and pituitary.
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Molecular cloning, expression pattern, and immunocytochemical localization of a gonadotropin-releasing hormone-like molecule in the gastropod mollusk, Aplysia californica.
TL;DR: The isolation of the full-length cDNA of a GnRH-like molecule from the central nervous system of a gastropod mollusk, the sea hare Aplysia californica, provides valuable support for an ancient origin of GnRH during metazoan evolution and refute the possibility that oct-GnRH arose singly in cephalopods by convergent evolution.
Journal ArticleDOI
Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population
Pei-San Tsai,Suzanne M. Moenter,Hector Postigo,Mohammed El Majdoubi,Toni R. Pak,John C. Gill,Sreenivasan Paruthiyil,Sabine Werner,Richard I. Weiner +8 more
TL;DR: The results are the first to show, at the level of the organism, that FGFs are one of the important components involved in the formation and maintenance of the GnRH system.