P
Pengfei Liu
Researcher at Georgia Institute of Technology
Publications - 523
Citations - 14919
Pengfei Liu is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 57, co-authored 363 publications receiving 11694 citations. Previous affiliations of Pengfei Liu include Harbin Institute of Technology & Harvard University.
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Journal ArticleDOI
The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo
Qing Wang,Terryl Stacy,Janelle Miller,Amy F. Lewis,Ting Lei Gu,Xuemei Huang,John H. Bushweller,Jean Christophe Bories,Frederick W. Alt,Gabriella Ryan,Pengfei Liu,Anthony Wynshaw-Boris,Michael Binder,Miguel Marin-Padilla,Arlene H. Sharpe,Nancy A. Speck +15 more
TL;DR: It is demonstrated that homozygous mutation of the Cbfb gene results in the same phenotype as the Cbfa2 gene and that the CBFβ subunit is required for CBFα2 function in vivo.
Journal ArticleDOI
Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis.
TL;DR: A critical role for pyrin in the innate immune response, possibly by acting on ASC, is supported and a biologic basis for the selection of hypomorphic pyrIn variants in man is suggested.
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Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5
Xiao Yang,Lucio H. Castilla,Xiaoling Xu,Cuiling Li,Jessica Gotay,Michael Weinstein,Pengfei Liu,Chu-Xia Deng +7 more
TL;DR: It is shown that Smad5 was expressed predominantly in mesenchyme and somites during embryogenesis, and in many tissues of the adult, and that it is essential for mesenchymal survival.
Journal ArticleDOI
Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice
Jae Jin Chae,Young-Hun Cho,Geun-Shik Lee,Jun Cheng,Pengfei Liu,Lionel Feigenbaum,Stephen I. Katz,Daniel L. Kastner +7 more
TL;DR: The data provide evidence for an ASC-dependent NLRP3-independent inflammasome in which gain-of-function pyrin mutations cause autoinflammatory disease.
Journal ArticleDOI
Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice.
Ryuya Yamanaka,Carrolee Barlow,Julie A. Lekstrom-Himes,Lucio H. Castilla,Pengfei Liu,Michael Eckhaus,Thomas Decker,Anthony Wynshaw-Boris,Kleanthis G. Xanthopoulos +8 more
TL;DR: End-stage mice develop myelodysplasia, characterized by proliferation of atypical granulocytes that efface the bone marrow and result in severe tissue destruction.