P
Per Nilsson
Researcher at Karolinska Institutet
Publications - 114
Citations - 9816
Per Nilsson is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 25, co-authored 82 publications receiving 7340 citations. Previous affiliations of Per Nilsson include RIKEN Brain Science Institute & Karolinska University Hospital.
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Journal ArticleDOI
Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates
Karin Sörgjerd,Tamotsu Zako,Masafumi Sakono,Peter C. Stirling,Michel R. Leroux,Takashi Saito,Per Nilsson,Misaki Sekimoto,Takaomi C. Saido,Mizuo Maeda +9 more
TL;DR: The findings show a relation between cytotoxicity of Aβ oligomers and structure and suggest a possible protective role of PFD in AD.
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Colectomy prior to diagnosis of primary sclerosing cholangitis is associated with improved prognosis in a nationwide cohort study of 2594 PSC-IBD patients
Caroline Nordenvall,Caroline Nordenvall,Ola Olén,Ola Olén,Per Nilsson,Per Nilsson,E. von Seth,Anders Ekbom,Matteo Bottai,Pär Myrelid,Annika Bergquist +10 more
TL;DR: Despite the close relationship between primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD), the association between colectomy and the prognosis of PSC remains controversial.
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Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro.
Gefei Chen,Yuniesky Andrade-Talavera,Simone Tambaro,Axel Leppert,Harriet Nilsson,Xueying Zhong,Michael Landreh,Per Nilsson,Hans Hebert,Henrik Biverstål,André Fisahn,Axel Abelein,Jan Johansson +12 more
TL;DR: A mutated BRICHOS molecular chaperone domain from the dementia associated Bri2 can reduce toxicity of amyloid formation in mouse hippocampus in vitro and is suggested to enhance anti-Aβ42 neurotoxic effects.
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Recent Advances in the Modeling of Alzheimer’s Disease
Hiroki Sasaguri,Shoko Hashimoto,Naoto Watamura,Kaori Sato,Risa Takamura,Kenichi Nagata,Satoshi Tsubuki,Toshio Ohshima,Atsushi Yoshiki,Kenya Sato,Wakako Kumita,Erika Sasaki,Shinobu Kitazume,Per Nilsson,Bengt Winblad,Takashi Saito,Nobuhisa Iwata,Takaomi C. Saido +17 more
TL;DR: A technical guide for the application of App knock-in mice to AD research is provided and a new model of cerebral amyloid angiopathy that may be useful for analyzing amyloids-related imaging abnormalities that can be caused by anti-Aβ immunotherapy is introduced.
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Tumour budding correlates with local recurrence of rectal cancer.
TL;DR: Predictive tools for local recurrence of rectal cancer are needed and the predictive value of tumour budding detected by MNF‐116 and laminin‐5 γ2 chain is assessed.