P
Per Nilsson
Researcher at Karolinska Institutet
Publications - 114
Citations - 9816
Per Nilsson is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 25, co-authored 82 publications receiving 7340 citations. Previous affiliations of Per Nilsson include RIKEN Brain Science Institute & Karolinska University Hospital.
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Journal ArticleDOI
Amyloid Β-Peptide Increases Mitochondria-Endoplasmic Reticulum Contact Altering Mitochondrial Function and Autophagosome Formation in Alzheimer's Disease-Related Models
Nuno Santos Leal,Giacomo Dentoni,Bernadette Schreiner,Luana Naia,Antonio Piras,Caroline Graff,Antonio Cattaneo,Giovanni Meli,Maho Hamasaki,Per Nilsson,Maria Ankarcrona +10 more
TL;DR: It is reported that Aβ can affect cell homeostasis by modulating MERCS and, consequently, altering mitochondrial activity and autophagosome formation and the data suggests that MERCS is a potential target for drug discovery in AD.
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Pelvic Exenteration for Recurrent Gynecologic Malignancy: A Study of 28 Consecutive Patients at a Single Institution
TL;DR: Pelvic exenteration for recurrent gynecologic malignancies can be associated with long-term survival in selected patients, however, postoperative complications are common and can be lethal.
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Factors Influencing Local Failure in Rectal Cancer: Analysis of 2315 Patients From a Population-Based Series
TL;DR: The variability of patient outcome according to local failure depends on tumor stage, nodal stage, and location, which are important additional risk factors to consider when optimizing treatment for rectal cancer.
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Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the AppNL-G-F mouse model of Alzheimer's disease.
Luis Enrique Arroyo-García,Arturo G. Isla,Yuniesky Andrade-Talavera,Hugo Balleza-Tapia,Raúl Loera-Valencia,Laura Alvarez-Jimenez,Giusy Pizzirusso,Simone Tambaro,Per Nilsson,André Fisahn +9 more
TL;DR: In Alzheimer's disease, the accumulation of amyloid-β (Aβ) correlates with degradation of cognition-relevant gamma oscillations as discussed by the authors, and the degradation correlates with increased Aβ1-42 concentration in the brain.
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An App knock-in rat model for Alzheimer's disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments.
Keliang Pang,Keliang Pang,Keliang Pang,Richeng Jiang,Richeng Jiang,Wei Zhang,Zhengyi Yang,Linlin Li,Makoto Shimozawa,Simone Tambaro,Johanna Mayer,B. Zhang,Man Li,Jiesi Wang,Hang Liu,Hang Liu,Hang Liu,Ailing Yang,Xi Chen,Liu J,Bengt Winblad,Bengt Winblad,Hua Han,Tianzi Jiang,Weiwen Wang,Per Nilsson,Wei Guo,Wei Guo,Wei Guo,Bai Lu,Bai Lu,Bai Lu +31 more
TL;DR: This article generated a rat model, with three familiar App mutations and humanized Aβ sequence knocked into the rat App gene, which exhibited pathologies and disease progression resembling those in human patients.