Peter Birrer

TL;DR: In CF patients with established lung disease, Pseudomonas aeruginosa was located within hypoxic mucopurulent masses in airway lumens, and in vitro studies revealed that CF-specific increases in epithelial O(2) consumption, linked to increased airway surface liquid (ASL) volume absorption and mucus stasis, generated steep hypoxic gradients within thickened mucus on CF epithelial surfaces prior to infection.

TL;DR: Identification of altered bronchoalveolar lavage fluid proteins may give new insights into pathogenic mechanisms and provide new targets for therapy.

TL;DR: It is demonstrated that inhalation of α1‐PI is associated with biochemical changes consistent with reduced proteolysis, and the display of the BAL proteome by two‐dimensional electrophoresis may be helpful to quantify the overall molecular changes associated with proteolytic or other lung injuries and offers the possibility to monitor directly therapeutic interventions.

TL;DR: The variable disease findings in infants with cystic fibrosis is clinically and functionally reflected by features already present at time of diagnosis, and the degree of pulmonary hyperinflation is, at least partly, influenced by the genotype.

TL;DR: The results indicate the rather common occurrence of chronic metabolic alkalosis in cystic fibrosis, observed in young patients, in patients who need high doses of pancreatic enzymes and in the those with poor nutritional status.