Peter Hansell

TL;DR: Many experimental studies provide evidence for a greater perturbation in renal functions by dimeric contrast media in comparison to nonionic monomers as the widely used nonionic low osmolar contrast media.

TL;DR: It is concluded that oxidative stress occurs in kidneys of diabetic rats predominantly in the medullary region and relates to augmented oxygen consumption and impaired oxygen tension in the tissue.

TL;DR: It is indicated that primary neutrophil interaction with inflamed EC through the L-selectin is a prerequisite for neutrophils function at physiological shear rates in vivo.

TL;DR: Good knowledge is gained about major changes in O2 metabolism occurring in diabetic and hypertensive kidneys, however, further efforts are needed to elucidate how these alterations can be prevented or reversed before translation into clinical practice.

TL;DR: Activation of HIFs prevents diabetes-induced alteration in kidney oxygen metabolism by normalizing glomerular filtration, which reduces tubular electrolyte load, preventing mitochondrial leak respiration and improving tubular transport efficiency, which could be related to reduced oxidative stress and account for the reduced proteinuria and tubulointerstitial damage.