P
Peter Heywood
Researcher at Frenchay Hospital
Publications - 12
Citations - 3539
Peter Heywood is an academic researcher from Frenchay Hospital. The author has contributed to research in topics: Glial cell line-derived neurotrophic factor & Subthalamic nucleus. The author has an hindex of 9, co-authored 11 publications receiving 3412 citations. Previous affiliations of Peter Heywood include University of Toronto.
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Journal ArticleDOI
Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease
Steven S. Gill,Nikunj K. Patel,Gary Hotton,Karen O’Sullivan,Renée McCarter,Martin Bunnage,David J. Brooks,Clive N. Svendsen,Peter Heywood +8 more
TL;DR: Positron emission tomography scans of [18F]dopamine uptake showed a significant 28% increase in putamen dopamine storage after 18 months, suggesting a direct effect of GDNF on dopamine function, and warrants careful examination ofGDNF as a treatment for Parkinson disease.
Journal ArticleDOI
Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease.
Anthony E. Lang,Steven S. Gill,Nik K. Patel,Andres M. Lozano,John G. Nutt,Richard D. Penn,David J. Brooks,Gary Hotton,Elena Moro,Peter Heywood,Matthew Brodsky,Kim J. Burchiel,Patrick J. Kelly,Arif Dalvi,Burton L. Scott,Mark Stacy,Dennis A. Turner,V. G. Frederich Wooten,W. J. Elias,Edward R. Laws,Vijay Dhawan,A. Jon Stoessl,James Matcham,Robert J. Coffey,Michael Traub +24 more
TL;DR: This randomized controlled clinical trial was designed to confirm initial clinical benefits observed in a small, open‐label trial using intraputamenal (Ipu) infusion of recombinant human GDNF (liatermin).
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Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study.
TL;DR: After 2 years of continual GDNF infusion, there were no serious clinical side effects and no significant detrimental effects on cognition and health‐related quality‐of‐life measures showed general improvement over time.
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Delayed cerebral edema and fatal coma after minor head trauma : role of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine
E. E. Kors,Gisela M. Terwindt,Frans L. M. G. Vermeulen,Robin B. Fitzsimons,Philip Jardine,Peter Heywood,Seth Love,Arn M. J. M. van den Maagdenberg,Joost Haan,Rune R. Frants,Michel D. Ferrari +10 more
TL;DR: It is concluded that the novel S218L mutation in the CACNA1A calcium channel subunit gene is involved in FHM and delayed fatal cerebral edema and coma after minor head trauma, which may have important implications for the understanding and treatment of this dramatic syndrome.
Journal ArticleDOI
Unilateral subthalamotomy in the treatment of Parkinson's disease.
TL;DR: Unilateral STN lesions can be made safely and are an effective alternative to thalamotomy, pallidotomy and unilateral STN DBS for the treatment of asymmetrical tremor-dominant advanced Parkinson's disease.