P
Peter Klatt
Researcher at Spanish National Research Council
Publications - 68
Citations - 11413
Peter Klatt is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Nitric oxide synthase & Tetrahydrobiopterin. The author has an hindex of 46, co-authored 68 publications receiving 11082 citations. Previous affiliations of Peter Klatt include Carlos III Health Institute & University of Graz.
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Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
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Regulation of protein function by S-glutathiolation in response to oxidative and nitrosative stress.
Peter Klatt,Santiago Lamas +1 more
TL;DR: A review of recent work supporting a role for S-glutathiolation in stress signalling pathways and in the adaptive cellular response to oxidative and nitrosative stress and the molecular mechanisms of protein regulation by oxidative andNitrosative thiol-group modifications are outlined.
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Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase.
TL;DR: According to these results, activation of brain NO synthase by Ca2+ at subphysiological levels of intracellular L-arginine or H4biopterin may result in the formation of reactive oxygen species instead of NO, and N omega-nitro-substituted L- arginine analogues represent useful tools to effectively block No synthase-catalysed oxygen activation.
Journal ArticleDOI
Defective smooth muscle regulation in cGMP kinase I‐deficient mice
Alexander Pfeifer,Peter Klatt,Steffen Massberg,Lars Ny,Matthias Sausbier,Christoph Hirneiß,Ge‐Xing Wang,Michael Korth,Attila Aszódi,Karl-Erik Andersson,Fritz Krombach,Artur Mayerhofer,Peter Ruth,Reinhard Fässler,Franz Hofmann +14 more
TL;DR: It is shown that cAMP and cGMP signal via independent pathways, with cGKI being the specific mediator of the NO/cGMP effects in murine smooth muscle.
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"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally.
Isabel Garcia-Cao,Marta García-Cao,Juan Martín-Caballero,Luis M. Criado,Peter Klatt,Juana M. Flores,Jean-Claude Weill,Maria A. Blasco,Manuel Serrano +8 more
TL;DR: The generation and characterization of mice carrying supernumerary copies of the p53 gene in the form of large genomic transgenes are reported, proving that cancer resistance can be enhanced by a simple genetic modification and in the absence of undesirable effects.