Peter L. Gor'kov

TL;DR: Exactly how well the native membrane needs to be modeled to achieve a native membrane protein structure is explored here, where the structure of the tetrameric M2 conductance domain (M2CD; residues 22–62; PDB #2L0J) that has been structurally characterized in synthetic lipid bilayers is validated.

TL;DR: The findings suggest that CA escapes from CypA dependence through dynamic allostery, which may not be primarily associated with a structural change of the capsid core, but with altering its dynamics, such as the reduction of motions for the CypA loop.

TL;DR: Findings provide support for the role of SP1 as a trigger of the disassembly of the immature CA capsid for its subsequent de novo reassembly into mature cores and establish the importance of sequence-dependent conformational plasticity in CA assembly.

TL;DR: Both in vivo large rodent MR imaging and localized spectroscopy at the extremely high field of 21.1 T are feasible and demonstrate improved resolution and sensitivity valuable for structural and functional brain analysis.

TL;DR: The structure of ASR is largely conserved in the inner membrane of E. coli, with many of the important structural features of rhodopsins previously observed in ASR in proteoliposomes being preserved.