P
Peter M. Colman
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 192
Citations - 25194
Peter M. Colman is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Neuraminidase & Virus. The author has an hindex of 69, co-authored 189 publications receiving 24117 citations. Previous affiliations of Peter M. Colman include University of Hertfordshire & Commonwealth Scientific and Industrial Research Organisation.
Papers
More filters
Journal ArticleDOI
Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides.
Paul Wyatt,Barry A. Coomber,Derek N. Evans,Torquil I. Jack,Heather E. Fulton,Alan J. Wonacott,Peter M. Colman,Jose Varghese +7 more
TL;DR: Potent inhibitors of influenza A sialidase with marked selectivity over the influenza B enzyme were obtained when the basic 4-amino substituent was replaced by hydroxyl or even deleted.
Journal ArticleDOI
Modelling the structure of the fusion protein from human respiratory syncytial virus.
TL;DR: Despite very low sequence homology between the two structures, most features of the model appear to have high credibility, although a few small regions in RSV-F whose secondary structure is predicted to be different to that in NDV are likely to be poorly modelled.
Journal ArticleDOI
Design and synthesis of carbohydrate-based inhibitors of protein-carbohydrate interactions.
TL;DR: A significant number of carbohydrate-metabolizing enzyme crystal structures have been solved which provide useful starting points for computer-assisted drug design and implicated in playing roles in human-disease states.
Patent
Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus
TL;DR: In this paper, a pharmacologically active composition of the invention comprises (i) a virus-inhibiting amount of a compound that binds the active site of influenza virus neuraminidase and that displays in vivo activity against orthomyxovirus or paramyxovirus; and (ii) a pharmaceutically acceptable carrier for the compound which is preferably suitable for intranasal administration.
Journal ArticleDOI
Gene and protein sequence of an influenza neuraminidase with hemagglutinin activity
TL;DR: This work has cloned a full-length copy of the coding sequence of the N9 NA of influenza virus A/tern/Australia/G70C/75 into the plasmid pUC9 using SalI linkers and found no significant homology to any known HA sequence, or to the HN protein of the paramyxovirus SV5.