Peter Schotte

TL;DR: The ability of truncated Bid (tBid) to induce the release of a DNAse activity from mitochondria during apoptosis was confirmed in the liver from mice injected with agonistic anti-Fas antibody and is completely prevented in Bcl-2 transgenic mice.

TL;DR: It is shown that a biotinylated fluoromethyl ketone peptide inhibitor of caspases (z‐VAD.fmk) also efficiently affinity‐labeled cathepsin B and cat hepsin H and efficiently inhibited cathePSin B activity in vitro and in tissue culture cells at concentrations that are generally used to demonstrate the involvement ofcaspases.

TL;DR: It is shown that polyinosinic:polycytidylic acid and lipopolysaccharide stimulation of macrophages induces pro–IL-1β processing via a Toll/ IL-1R domain–containing adaptor-inducing interferon-β–dependent signaling pathway that is initiated by TLR3 and TLR4, respectively.

TL;DR: A previously unknown function of Rho GTPases in the activation of caspase-1 is highlighted and new insight is given on the role of YopE in immune-escape mechanisms of Yersinia.

TL;DR: The results suggest a potential role for lysosomes and cathepsin B as activators of specific proinflammatory caspases in the proinflammatory CASP-11.