P
Peter W. Andrews
Researcher at University of Sheffield
Publications - 286
Citations - 22367
Peter W. Andrews is an academic researcher from University of Sheffield. The author has contributed to research in topics: Embryonic stem cell & Cellular differentiation. The author has an hindex of 71, co-authored 280 publications receiving 21323 citations. Previous affiliations of Peter W. Andrews include East Sussex County Council & Wistar Institute.
Papers
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Journal ArticleDOI
DNMT3B inhibits the re-expression of genes associated with induced pluripotency.
TL;DR: It is found that DNMT3B is rapidly down-regulated in human ES cells during retinoic acid (RA)-induced differentiation compared withDNMT3A2, which is also highly expressed in ES cells, and that silencing of DN MT3B facilitates the generation of cells that bear the hallmarks of pluripotency.
Book ChapterDOI
The Characteristics of Cell Lines Derived from Human Germ Cell Tumors
TL;DR: Analysis of well-defined cell lines corresponding to the different components of these tumors may help to clarify existing histological classifications, and to provide new criteria for more sound diagnosis and assessment of methods of treatment.
Journal ArticleDOI
DNA-binding proteins that interact with the 19-base pair (CRE-like) element from the HCMV major immediate early promoter in differentiating human embryonal carcinoma cells
Karoly Rideg,Gabor Hirka,Kesh Prakash,Lauretta M. Bushar,Jean-Yves Nothias,Roberto Weinmann,Peter W. Andrews,Eva Gonczol +7 more
TL;DR: The activity of these proteins decreased markedly after differentiation, indicating their involvement in negative regulation of the CRE/AP1-like site in undifferentiated EC cells and suggests novel members able to interact via leucine zippers with other members of the Jun-Fos-CREB family of DNA binding proteins that are also involved in this regulation.
Journal ArticleDOI
Culture adaptation alters transcriptional hierarchies among single human embryonic stem cells reflecting altered patterns of differentiation.
Paul J. Gokhale,Janice K. Au-Young,SriVidya Dadi,David N. Keys,Neil J. Harrison,Mark Jones,Shamit Soneji,Tariq Enver,Jon K. Sherlock,Peter W. Andrews +9 more
TL;DR: The results suggest that the selective growth advantage gained by genetically variant, culture adapted human embryonic stem cells may derive in part from a changed substate structure that influences their propensity for differentiation.
Journal ArticleDOI
Trophectodermal carcinoma: mouse teratocarcinoma-derived tumour stem cells differentiating into trophoblastic and yolk sac elements.
TL;DR: Solid tumours produced from subcutaneously injected cells had a variegated appearance suggesting, that like the limited differentiation in the ascites, the stem cells can give rise to trophoblastic, as well as parietal and visceral yolk sac elements.