P
Peter W. Reeh
Researcher at University of Erlangen-Nuremberg
Publications - 187
Citations - 13190
Peter W. Reeh is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Calcitonin gene-related peptide & TRPV1. The author has an hindex of 61, co-authored 180 publications receiving 12118 citations. Previous affiliations of Peter W. Reeh include Heidelberg University & University of Pécs.
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Journal ArticleDOI
The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors
Michael Fischer,Andreas Leffler,Florian Niedermirtl,Katrin Kistner,Mirjam Eberhardt,Peter W. Reeh,Carla Nau +6 more
TL;DR: TRPV1 and TRPA1 are identified as key molecules for propofol-induced excitation of sensory neurons, and further investigations into the role of anesthetics to induce nociceptor sensitization and to foster postoperative pain are warranted.
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The Molecular Basis for Species-specific Activation of Human TRPA1 Protein by Protons Involves Poorly Conserved Residues within Transmembrane Domains 5 and 6
Mirjam Eberhardt,Alexandra B. Klinger,Nancy Stanslowsky,Florian Wegner,Wolfgang Koppert,Peter W. Reeh,Angelika Lampert,Michael Fischer,Andreas Leffler +8 more
TL;DR: The data suggest that hTRPA1 acts as a sensor for extracellular acidosis in human sensory neurons and should thus be taken into account as a yet unrecognized transduction molecule for proton-evoked pain and inflammation.
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Transient opening of the perineurial barrier for analgesic drug delivery
Dagmar Hackel,Susanne M. Krug,Reine-Solange Sauer,Shaaban A. Mousa,Alexander Böcker,Diana Pflücke,Esther-Johanna Wrede,Katrin Kistner,Tali Hoffmann,Benedikt Niedermirtl,Claudia Sommer,Laura Bloch,Otmar Huber,Ingolf E. Blasig,Salah Amasheh,Peter W. Reeh,Michael Fromm,Alexander Brack,H.L. Rittner +18 more
TL;DR: The function and regulation of claudin-1 in the perineurium as the major sealing component is established, which could be modulated to facilitate drug delivery or, potentially, reseal the barrier under pathological conditions.
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Muscarinic M2 Receptors on Peripheral Nerve Endings: A Molecular Target of Antinociception
TL;DR: Data provide direct evidence that M2 receptors on cutaneous nerve endings mediate effective depression of nociceptive responsiveness and should be of interest for the development of novel classes of analgesic agents.
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A technique for fast application of heated solutions of different composition to cultured neurones.
Ivan Dittert,Viktorie Vlachova,Helena Knotková,Zdenka Vitásková,Ladislav Vyklicky,M. Kress,Peter W. Reeh +6 more
TL;DR: The technique is used for classifying sensory neurones in culture with respect to their sensitivity to heat and algogens; however, it is applicable to any study of the effects of increased temperature on the activity of ion channels in cultured cells.