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Ingolf E. Blasig
Researcher at Leibniz Institute for Neurobiology
Publications - 132
Citations - 8217
Ingolf E. Blasig is an academic researcher from Leibniz Institute for Neurobiology. The author has contributed to research in topics: Tight junction & Claudin. The author has an hindex of 50, co-authored 130 publications receiving 7319 citations. Previous affiliations of Ingolf E. Blasig include Leibniz Association & University of Würzburg.
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Journal ArticleDOI
Structure and function of claudins.
Gerd Krause,Lars Winkler,Sebastian L. Mueller,Reiner F. Haseloff,Jörg Piontek,Ingolf E. Blasig +5 more
TL;DR: The concepts evolved from these findings and first tentative molecular models for homophilic interactions may explain the different functional contribution of the two extracellular loops at tight junctions.
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Formation of tight junction: determinants of homophilic interaction between classic claudins
Jörg Piontek,Lars Winkler,Hartwig Wolburg,Sebastian L. Müller,Nikolaj Zuleger,Nikolaj Zuleger,Christian Piehl,Burkhard Wiesner,Gerd Krause,Ingolf E. Blasig +9 more
TL;DR: The claudin‐claudin interaction and tight junction strand formation were investigated using systematic single mutations and an antiparallel homodimer homology model of the loop led to a novel molecular concept for tight junction formation.
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Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling
Gerty Schreibelt,Gijs Kooij,Arie Reijerkerk,Ruben van Doorn,Sonja I Gringhuis,Susanne M. A. van der Pol,Babette B. Weksler,Ignacio A. Romero,Pierre-Olivier Couraud,Jörg Piontek,Ingolf E. Blasig,Christine D. Dijkstra,Eric Ronken,Helga E. de Vries +13 more
TL;DR: It is demonstrated that ROS alter BBB integrity, which is paralleled by cytoskel‐eton rearrangements and redistribution and disappearance of TJ proteins claudin‐5 and occludin, which provides novel opportunities for the treatment of neuroinflammatory diseases.
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Locally renewing resident synovial macrophages provide a protective barrier for the joint
Stephan Culemann,Anika Grüneboom,José Ángel Nicolás-Ávila,Daniela Weidner,Katrin Franziska Lämmle,Tobias Rothe,Juan A. Quintana,Philipp Kirchner,Branislav Krljanac,Martin Eberhardt,Fulvia Ferrazzi,Elke Kretzschmar,Martin Schicht,Kim Fischer,Kolja Gelse,Maria Faas,R Pfeifle,Jochen A. Ackermann,Milena L Pachowsky,Nina Renner,David Simon,Reiner F. Haseloff,Arif B. Ekici,Tobias Bäuerle,Ingolf E. Blasig,Julio Vera,David Voehringer,Arnd Kleyer,Friedrich Paulsen,Georg Schett,Andrés Hidalgo,Gerhard Krönke +31 more
TL;DR: Analysis of macrophage subsets within joints reveals a population of CX3CR1+ tissue-resident macrophages that form a tight-junction-mediated barrier at the synovial lining, protecting the joint from the invasion of inflammatory cells.
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In search of the astrocytic factor(s) modulating blood-brain barrier functions in brain capillary endothelial cells in vitro
TL;DR: The knowledge on this subject is far from being complete, however, these data imply that the neural/neuronal environment rather than glial cells may be of importance in the maturation of the barrier, which indicates that the cornerstone is laid.