P
Peter W. Reeh
Researcher at University of Erlangen-Nuremberg
Publications - 187
Citations - 13190
Peter W. Reeh is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Calcitonin gene-related peptide & TRPV1. The author has an hindex of 61, co-authored 180 publications receiving 12118 citations. Previous affiliations of Peter W. Reeh include Heidelberg University & University of Pécs.
Papers
More filters
Journal ArticleDOI
Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: a review.
Jürgen Wess,Alokesh Duttaroy,Jesus Gomeza,Weilie Zhang,Masahisa Yamada,Christian C. Felder,Nadia Bernardini,Peter W. Reeh +7 more
TL;DR: The usefulness of muscarinic receptor mutant mice to shed light on the functional roles of acetylcholine released from both neuronal and non-neuronal cells is highlighted.
Journal ArticleDOI
Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling
Irina Vetter,Filip Touska,Filip Touska,Andreas Hess,Rachel Hinsbey,Simon Sattler,Angelika Lampert,Marina Sergejeva,Anastasia Sharov,Lindon S. Collins,Mirjam Eberhardt,Matthias Engel,Peter J. Cabot,John N. Wood,Viktorie Vlachova,Peter W. Reeh,Richard J. Lewis,Katharina Zimmermann +17 more
TL;DR: It is shown that intraplantar injection of P‐CTX‐1 elicits cold allodynia in mice by targeting specific unmyelinated and myelinated primary sensory neurons, confirming an important role for TRPA1 in the pathogenesis of cold allODYnia.
Journal ArticleDOI
Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity
Lavanya Moparthi,Tatjana I. Kichko,Mirjam Eberhardt,Edward D. Högestätt,Per Kjellbom,Urban Johanson,Peter W. Reeh,Andreas Leffler,Milos R. Filipovic,Peter M. Zygmunt +9 more
TL;DR: It is shown that redox modification and ligands affect human TRPA1 (hTRPA1) cold and heat sensing properties in lipid bilayer and whole-cell patch-clamp recordings as well as heat-evoked TRPA 1-dependent calcitonin gene-related peptide (CGRP) release from mouse trachea.
Journal ArticleDOI
Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing
Christian Brenneis,Katrin Kistner,Michelino Puopolo,David Segal,David Roberson,Marco Sisignano,Sandra Labocha,Nerea Ferreirós,Amanda Strominger,Enrique J. Cobos,Nader Ghasemlou,Gerd Geisslinger,Peter W. Reeh,Bruce P. Bean,Clifford J. Woolf,Clifford J. Woolf +15 more
TL;DR: The results indicate that TRPV1-expressing sensory neurons process particular thermal and mechanical somatosensations, and that the sensory channels activated by mechanical and cold stimuli to produce pain in naive/inflamed rats differ from those in animals after peripheral nerve injury.
Journal ArticleDOI
Local Anesthetic-like Inhibition of Voltage-gated Na+Channels by the Partial μ-opioid Receptor Agonist Buprenorphine
Andreas Leffler,Georg Frank,Katrin Kistner,Florian Niedermirtl,Wolfgang Koppert,Peter W. Reeh,Carla Nau +6 more
TL;DR: Buprenorphine is a potent localAnesthetic and blocks voltage-gated Na+ channels via the local anesthetic binding site and is likely to be relevant when buprenorphines is used for pain treatment and for local anesthesia.