P
Petr Strnad
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 13
Citations - 1291
Petr Strnad is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Centrosome & Centriole. The author has an hindex of 9, co-authored 13 publications receiving 1067 citations. Previous affiliations of Petr Strnad include Friedrich Miescher Institute for Biomedical Research & European Bioinformatics Institute.
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Journal ArticleDOI
Regulated HsSAS-6 Levels Ensure Formation of a Single Procentriole per Centriole during the Centrosome Duplication Cycle
Petr Strnad,Sebastian A. Leidel,Tatiana Vinogradova,Ursula Euteneuer,Alexey Khodjakov,Pierre Gönczy +5 more
TL;DR: In this article, the authors show that HsSAS-6 is necessary for centrosome formation and that it localizes asymmetrically next to the centriole at the onset of procentriole formation.
Journal ArticleDOI
Self-organization and symmetry breaking in intestinal organoid development
Denise Serra,Denise Serra,Urs Mayr,Urs Mayr,Andrea Boni,Andrea Boni,Ilya Lukonin,Ilya Lukonin,Markus Rempfler,Ludivine Challet Meylan,Michael B. Stadler,Michael B. Stadler,Petr Strnad,Petr Strnad,Panagiotis Papasaikas,Panagiotis Papasaikas,Dario Vischi,Annick Waldt,Guglielmo Roma,Prisca Liberali,Prisca Liberali +20 more
TL;DR: These findings reveal how single cells exposed to a uniform growth-promoting environment have the intrinsic ability to generate emergent, self-organized behaviour that results in the formation of complex multicellular asymmetric structures.
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Mechanisms of procentriole formation
Petr Strnad,Pierre Gönczy +1 more
TL;DR: Recent findings are reviewed that provide important mechanistic insights into how a single procentriole forms next to each centriole once per cell cycle, thus ensuring that one centrosome becomes two.
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Inverted light-sheet microscope for imaging mouse pre-implantation development
Petr Strnad,Stefan Gunther,Judith Reichmann,Uros Krzic,Bálint Balázs,Gustavo de Medeiros,Nils Norlin,Takashi Hiiragi,Lars Hufnagel,Jan Ellenberg +9 more
TL;DR: An inverted light-sheet microscope is developed that is able to image mouse embryos from zygote to blastocyst, computationally track all cells and reconstruct a complete lineage tree of mouse pre-implantation development, and shows that the first cell fate specification occurs at the 16-cell stage.
Journal ArticleDOI
Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL.
Daiju Kitagawa,Gregor Kohlmaier,Debora Keller,Petr Strnad,Fernando R. Balestra,Isabelle Flückiger,Pierre Gönczy +6 more
TL;DR: This work identifies CPAP protein domains crucial for its centriolar localization, as well as for the elongation and the formation of centrioles, and demonstrates that the MCPH protein SCL/TAL1 interrupting locus (STIL) is also essential for centriole formation and for proper spindle position.