Pierre Gönczy

TL;DR: This work used RNA-mediated interference to target 98% of all genes predicted in the C. elegans genome in combination with differential interference contrast time-lapse microscopy and developed a phenotypic profiling system, which shows high correlation with cellular processes and biochemical pathways, thus enabling to predict new functions for previously uncharacterized genes.

TL;DR: A functional genomic screen to identify genes required for cell division in Caenorhabditis elegans using an in vivo time-lapse differential interference contrast microscopy assay and found that this screen provides putative gene functions for other species as well.

TL;DR: A mechanism for generating asymmetry in spindle positioning is suggested by varying the net pulling force that acts on each spindle pole, thus allowing for the generation of daughter cells with different sizes.

TL;DR: The mechanisms that govern asymmetric cell division in Drosophila melanogaster and Caenorhabditis elegans also apply to cells that divide asymmetrically in other metazoans, such as self-renewing stem cells in mammals.

TL;DR: It is shown that changing a single amino acid at the C-terminus of the recognition helix is both necessary and sufficient to confer the DNA binding specificity of either Ftz or Bcd on Prd, which contains two DNA binding activities.