P
Philip A. Poole-Wilson
Researcher at National Institutes of Health
Publications - 443
Citations - 69648
Philip A. Poole-Wilson is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Heart failure & Heart disease. The author has an hindex of 105, co-authored 443 publications receiving 66861 citations. Previous affiliations of Philip A. Poole-Wilson include Harefield Hospital & St George's Hospital.
Papers
More filters
Journal ArticleDOI
Endothelin-1 Is Involved in Norepinephrine-Induced Ventricular Hypertrophy In Vivo Acute Effects of Bosentan, an Orally Active, Mixed Endothelin ETA and ETB Receptor Antagonist
TL;DR: Analysis of the effects of continuous norepinephrine infusion on physical and molecular markers of ventricular hypertrophy, ventricular and noncardiac expression of ET-1 mRNA, and the acute effects of bosentan suggests that endogenousET-1 plays a direct role in mediating nore Pinephrine-induced ventricularhypertrophy in vivo.
Journal ArticleDOI
Effects of metoprolol and carvedilol on pre-existing and new onset diabetes in patients with chronic heart failure: data from the Carvedilol Or Metoprolol European Trial (COMET)
Christian Torp-Pedersen,Marco Metra,Andrew Charlesworth,Phillip Spark,Mary Ann Lukas,Philip A. Poole-Wilson,Karl Swedberg,John G.F. Cleland,Andrea Di Lenarda,Willem J. Remme,Armin Scherhag +10 more
TL;DR: A high prevalence and incidence of diabetes is found in patients with heart failure over a course of 5 years, and new onset diabetes is more likely to occur during treatment with metoprolol than duringtreatment with carvedilol.
Journal ArticleDOI
Effect of anemia on exercise tolerance in chronic heart failure in men.
Paul R. Kalra,Aidan P. Bolger,Darrel P. Francis,Sabine Genth-Zotz,Rakesh Sharma,Piotr Ponikowski,Philip A. Poole-Wilson,Andrew J.S. Coats,Stefan D. Anker,Stefan D. Anker +9 more
TL;DR: Within-patient comparison of effects of different dosages of enalapril on functional capacity and neurohormone levels in patients with chronic heart failure and the "Escape” of aldosterone production in Patients with left ventricular dysfunction treated with an angiotensin converting enzyme inhibitor are compared.
Journal ArticleDOI
Effects of ischaemia and reperfusion on calcium exchange and mechanical function in isolated rabbit myocardium
TL;DR: The uptake of calcium was related to the severity and duration of ischaemia and to the degree of mechanical recovery, and was due to an increased influx which is not related to gross disruption of the cell membrane but more probably to a specific abnormality of ionic channels.