Philip A. Poole-Wilson

TL;DR: In patients with chronic HF, quadriceps maximal isometric strength is reduced and muscular atrophy becomes a major determinant of exercise capacity and is an independent predictor of peak absolute VO2.

TL;DR: Coronary artery disease is the cause of 52% (95% CI 43-61%) of incident heart failure in the general population under 75 years and clinical assessment without angiography under-estimates the proportion of patients with coronary artery disease, and fails to identify those patients who may benefit from revascularization.

TL;DR: It is suggested that a calcium antagonistic property may be involved in the mechanism of rabbit coronary arterial relaxation by 17β‐oestradiol by an endothelium‐independent mechanism in vitro.

TL;DR: Patients with high soluble CD14 levels have markedly increased plasma levels of TNF-alpha, soluble TNF receptors 1 and 2, and intracellular adhesion molecule-1, supporting this hypothesis that in patients with chronic heart failure mesenteric venous congestion leads to increased bowel permeability, bacterial translocation, and thereby endotoxin release.

TL;DR: In patients with non-ST-elevation acute coronary syndrome, a routine invasive strategy leads to long-term reduction in risk of death or non-fatal myocardial infarction, and this benefit is mainly in high-risk patients.