P
Philip Beineke
Researcher at Vanderbilt University
Publications - 18
Citations - 481
Philip Beineke is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Coronary artery disease & Population. The author has an hindex of 7, co-authored 17 publications receiving 431 citations.
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Journal ArticleDOI
Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients.
Steven A. Rosenberg,Michael Elashoff,Philip Beineke,Susan E. Daniels,James A. Wingrove,Whittemore G. Tingley,Philip T. Sager,Amy J. Sehnert,May Yau,William E. Kraus,L. Kristin Newby,Robert S. Schwartz,Szilard Voros,Stephen G. Ellis,Naeem Tahirkheli,Ron Waksman,John A. McPherson,Alexandra J. Lansky,Mary E. Winn,Nicholas J. Schork,Eric J. Topol +20 more
TL;DR: A noninvasive whole-blood test based on gene expression and demographic characteristics may be useful for assessing obstructive CAD in nondiabetic patients without known CAD.
Journal ArticleDOI
Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients.
Michael Elashoff,James A. Wingrove,Philip Beineke,Susan E. Daniels,Whittemore G. Tingley,Steven A. Rosenberg,Szilard Voros,William E. Kraus,Geoffrey S. Ginsburg,Robert S. Schwartz,Stephen G. Ellis,Naheem Tahirkheli,Ron Waksman,John A. McPherson,Alexandra J. Lansky,Eric J. Topol +15 more
TL;DR: A whole blood classifier based on gene expression, age and sex for the assessment of obstructive CAD in non-diabetic patients is developed from a combination of microarray and RT-PCR data derived from studies of patients clinically indicated for invasive angiography.
Journal ArticleDOI
A whole blood gene expression-based signature for smoking status.
Philip Beineke,Karen Fitch,Heng Tao,Michael Elashoff,Steven A. Rosenberg,William E. Kraus,James A. Wingrove +6 more
TL;DR: A whole blood gene expression score is constructed and validated for the evaluation of smoking status, demonstrating that clinical and environmental factors contributing to cardiovascular disease risk can be assessed by gene expression.
Journal ArticleDOI
Identification of factors contributing to variability in a blood-based gene expression test.
Michael Elashoff,Rachel Nuttall,Philip Beineke,Michael H. Doctolero,Mark Dickson,Andrea Johnson,Susan E. Daniels,Steven A. Rosenberg,James A. Wingrove +8 more
TL;DR: Intra-batch variability inherent to the PCR process contributed the most to the overall variability in the study while reagent lot showed the largest contribution to inter- batch variability.
Journal ArticleDOI
Developing Smartphone-Based Objective Assessments of Physical Function in Rheumatoid Arthritis Patients: The PARADE Study
Valentin Hamy,Luis Garcia-Gancedo,Andrew Pollard,Anniek Myatt,Jingshu Liu,Andrew Howland,Philip Beineke,Emilia Quattrocchi,Rachel E. Williams,Michelle Crouthamel +9 more
TL;DR: The findings demonstrate the potential to capture and quantify meaningful objective clinical information remotely using iPhone sensors and represent an early step towards the development of patient-centric digital endpoints for clinical trials in rheumatoid arthritis.