Philip S. Guzelian

TL;DR: It is shown that targeted disruption of the mouse PXR gene abolishes induction of CYP3A by prototypic inducers such as dexamethasone or pregnenolone-16α-carbonitrile, and that SXR/PXR genes encode the primary species-specific xeno-sensors that mediate the adaptive hepatic response, and may represent the critical biochemical mechanism of human xenoprotection.

TL;DR: It is found that SXR can regulate CYP2B, both in cultured cells and in transgenic mice via adaptive recognition of the phenobarbital response element (PBRE), which provides a rational explanation for the activation of multiple CYP gene classes by certain xenobiotics.

TL;DR: It is concluded that the intestinal mucosa contains prominent form(s) of cytochromes P-450 similar to liver cytochrome P- 450p in their structure, function, and some regulatory characteristics.

TL;DR: It is concluded that hepatocytes cultured on matrigel, as opposed to the standard collagen, exhibit remarkably enhanced expression of many liver‐specific functions.

TL;DR: P phenotypic change occurs in primary hepatocyte culture, not only in mammalian but also in amphibian hepatocytes7; it is distinct from a process of senescence or impaired viability; and it may be quantitatively impressive, involving key hepatic functions.