P
Philipp A. Jaeger
Researcher at University of California, San Diego
Publications - 17
Citations - 2093
Philipp A. Jaeger is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Autophagy & Gene. The author has an hindex of 11, co-authored 17 publications receiving 1824 citations. Previous affiliations of Philipp A. Jaeger include University of California, San Francisco & Stanford University.
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Journal ArticleDOI
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
Fiona Pickford,Eliezer Masliah,Markus Britschgi,Kurt M. Lucin,Ramya Narasimhan,Philipp A. Jaeger,Philipp A. Jaeger,Scott A. Small,Brian Spencer,Edward Rockenstein,Beth Levine,Tony Wyss-Coray,Tony Wyss-Coray +12 more
TL;DR: It is concluded that beclin 1 deficiency disrupts neuronal autophagy, modulates APP metabolism, and promotes neurodegeneration in mice and that increasing beClin 1 levels may have therapeutic potential in AD.
Journal ArticleDOI
Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA.
Andrew M. Gross,Philipp A. Jaeger,Jason F. Kreisberg,Katherine Licon,Kristen Jepsen,Mahdieh Khosroheidari,Brenda Morsey,Susan Swindells,Hui Shen,Cherie T. Ng,Ken Flagg,Daniel Chen,Kang Zhang,Howard S. Fox,Trey Ideker +14 more
TL;DR: A global analysis of the whole-blood DNA methylomes of 137 HIV+ individuals under sustained therapy along with 44 matched HIV- individuals finds that decreased HLA methylation is predictive of lower CD4 / CD8 T cell ratio, linking molecular aging, epigenetic regulation, and disease progression.
Journal ArticleDOI
Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex
Philipp A. Jaeger,Fiona Pickford,Chung-Huan Sun,Kurt M. Lucin,Eliezer Masliah,Tony Wyss-Coray,Tony Wyss-Coray +6 more
TL;DR: It is reported that the levels of Amyloid precursor protein (APP) and its metabolites can be reduced through autophagy activation, indicating that they are a substrate for Autophagy.
Journal ArticleDOI
All-you-can-eat: autophagy in neurodegeneration and neuroprotection
TL;DR: The current knowledge of autophagy in the central nervous system is reviewed and an overview of the various models that have been used to study acute and chronic neurodegeneration is provided.
Journal ArticleDOI
TDP-43 frontotemporal lobar degeneration and autoimmune disease
Zachary A. Miller,Katherine P. Rankin,Neill R. Graff-Radford,Leonel T. Takada,Leonel T. Takada,Virginia E. Sturm,Clare M. Cleveland,Lindsey A. Criswell,Philipp A. Jaeger,Trisha Stan,Kristin Heggeli,Sandy Chan Hsu,Sandy Chan Hsu,Anna Karydas,Baber K. Khan,Lea T. Grinberg,Maria Luisa Gorno-Tempini,Adam L. Boxer,Howard J. Rosen,Joel H. Kramer,Giovanni Coppola,Giovanni Coppola,Daniel H. Geschwind,Daniel H. Geschwind,Rosa Rademakers,William W. Seeley,Tony Wyss-Coray,Bruce L. Miller +27 more
TL;DR: Findings suggest a unique pattern of systemic inflammation in svPPA and PGRN and open new research avenues for understanding and treating disorders associated with underlying transactive response DNA-binding protein 43 aggregation.