D
Daniel Chen
Researcher at University of California, San Diego
Publications - 9
Citations - 1945
Daniel Chen is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Progenitor cell & Cataracts. The author has an hindex of 7, co-authored 9 publications receiving 1432 citations. Previous affiliations of Daniel Chen include Advanced Micro Devices.
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Journal ArticleDOI
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Lars G. Fritsche,Wilmar Igl,Jessica N. Cooke Bailey,Felix Grassmann,Sebanti Sengupta,Jennifer L. Bragg-Gresham,Kathryn P. Burdon,Scott J. Hebbring,Cindy Wen,Mathias Gorski,Ivana K. Kim,David Cho,Donald J. Zack,Donald J. Zack,Eric H. Souied,Hendrik P. N. Scholl,Hendrik P. N. Scholl,Elisa Bala,Kristine ELee,David J. Hunter,Rebecca J. Sardell,Paul Mitchell,Joanna E. Merriam,Valentina Cipriani,Valentina Cipriani,Joshua D. Hoffman,Tina Schick,Yara T. E. Lechanteur,Robyn H. Guymer,Matthew P. Johnson,Yingda Jiang,Chloe M. Stanton,Gabri'lle H.S. Buitendijk,Xiaowei Zhan,Xiaowei Zhan,Alan M. Kwong,Alexis Boleda,Matthew Brooks,Linn Gieser,Rinki Ratnapriya,Kari Branham,Johanna R. Foerster,John R. Heckenlively,Mohammad Othman,Brendan J. Vote,Helena Liang,Emmanuelle Souzeau,Ian L. McAllister,Timothy Isaacs,Janette Hall,Stewart Lake,David A. Mackey,David A. Mackey,David A. Mackey,Ian J. Constable,Jamie E Craig,Terrie Kitchner,Zhenglin Yang,Zhenglin Yang,Zhiguang Su,Hongrong Luo,Daniel Chen,Hong Ouyang,Ken Flagg,Danni Lin,Guanping Mao,Henry Ferreyra,Klaus Stark,Claudia N von Strachwitz,Armin Wolf,Caroline Brandl,G. Rudolph,Matthias Olden,Margaux A. Morrison,Denise J. Morgan,Matthew Schu,Jeeyun Ahn,Giuliana Silvestri,Evangelia E. Tsironi,Kyu Hyung Park,Lindsay A. Farrer,Anton Orlin,Alexander J. Brucker,Mingyao Li,Christine A. Curcio,Saddek Mohand-Sa'd,José-Alain Sahel,Isabelle Audo,Mustapha Benchaboune,Angela J. Cree,Christina A Rennie,S. V. Goverdhan,Michelle Grunin,Shira Hagbi-Levi,Peter A. Campochiaro,Nicholas Katsanis,Frank G. Holz,Frédéric Blond,Frédéric Blond,Frédéric Blond,Hél'ne Blanché,Jean Fran ois Deleuze,Robert P. Igo,Barbara Truitt,Neal S. Peachey,Neal S. Peachey,Stacy M. Meuer,Chelsea E. Myers,Emily L. Moore,Ronald Klein,Michael A. Hauser,Eric A. Postel,Monique D. Courtenay,Stephen G. Schwartz,Jaclyn L. Kovach,William K. Scott,Gerald Liew,Ava Grace Tan,Bamini Gopinath,John C. Merriam,R. Theodore Smith,R. Theodore Smith,Jane C. Khan,Jane C. Khan,Jane C. Khan,Humma Shahid,Humma Shahid,Anthony T. Moore,Anthony T. Moore,Anthony T. Moore,J Allie McGrath,Renee Laux,Milam A. Brantley,Anita Agarwal,Lebriz Ersoy,Albert Caramoy,Thomas Langmann,Nicole T.M. Saksens,Eiko Kde Jong,Carel B. Hoyng,Melinda Cain,Andrea J. Richardson,Tammy M. Martin,John Blangero,Daniel E. Weeks,Bal Dhillon,Cornelia M. van Duijn,Kimberly F. Doheny,Jane Romm,Caroline C W Klaver,Caroline Hayward,Michael B. Gorin,Michael L. Klein,Paul N. Baird,Anneke I. den Hollander,Sascha Fauser,John R. WYates,John R. WYates,John R. WYates,Rando Allikmets,Jie Jin Wang,Debra A. Schaumberg,Debra A. Schaumberg,Barbara E.K. Klein,Stephanie A. Hagstrom,Itay Chowers,Andrew J. Lotery,Thierry Léveillard,Thierry Léveillard,Thierry Léveillard,Kang Zhang,Kang Zhang,Murray H. Brilliant,Alex W. Hewitt,Alex W. Hewitt,Alex W. Hewitt,Anand Swaroop,Emily Y. Chew,Margaret A. Pericak-Vance,Margaret M. DeAngelis,Dwight Stambolian,Jonathan L. Haines,Sudha K. Iyengar,Bernhard H. F. Weber,Gon'alo R. Abecasis,Iris M. Heid +185 more
TL;DR: The results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.
Journal ArticleDOI
Lanosterol reverses protein aggregation in cataracts
Ling Zhao,Xiang-Jun Chen,Jie Zhu,Yi-Bo Xi,Xu Yang,Li-Dan Hu,Hong Ouyang,Sherrina Patel,Xin Jin,Danni Lin,Frances Wu,Ken Flagg,Huimin Cai,Gen Li,Guiqun Cao,Ying Lin,Daniel Chen,Cindy Wen,Christopher Chung,Yandong Wang,Austin Qiu,Emily Yeh,Wenqiu Wang,Xun Hu,Seanna Grob,Ruben Abagyan,Zhiguang Su,Harry C. Tjondro,Xi-Juan Zhao,Hongrong Luo,Rui Hou,J. Jefferson,P. Perry,Weiwei Gao,Igor Kozak,David B. Granet,Yingrui Li,Xiaodong Sun,Jun Wang,Liangfang Zhang,Yizhi Liu,Yong-Bin Yan,Kang Zhang +42 more
TL;DR: In this paper, the authors identify two distinct homozygous LSS missense mutations (W581R and G588S) in two families with extensive congenital cataracts.
Journal ArticleDOI
Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA.
Andrew M. Gross,Philipp A. Jaeger,Jason F. Kreisberg,Katherine Licon,Kristen Jepsen,Mahdieh Khosroheidari,Brenda Morsey,Susan Swindells,Hui Shen,Cherie T. Ng,Ken Flagg,Daniel Chen,Kang Zhang,Howard S. Fox,Trey Ideker +14 more
TL;DR: A global analysis of the whole-blood DNA methylomes of 137 HIV+ individuals under sustained therapy along with 44 matched HIV- individuals finds that decreased HLA methylation is predictive of lower CD4 / CD8 T cell ratio, linking molecular aging, epigenetic regulation, and disease progression.
Journal ArticleDOI
Lens regeneration using endogenous stem cells with gain of visual function
Haotian Lin,Hong Ouyang,Jie Zhu,Shan Huang,Zhenzhen Liu,Shuyi Chen,Guiqun Cao,Gen Li,Robert A.J. Signer,Yanxin Xu,Christopher Chung,Ying Zhang,Danni Lin,Sherrina Patel,Frances Wu,Huimin Cai,Jiayi Hou,Cindy Wen,Maryam Jafari,Xialin Liu,Lixia Luo,Jin Zhu,Austin Qiu,Rui Hou,Baoxin Chen,Jiangna Chen,David B. Granet,Christopher W.D. Heichel,Fu Shang,Xuri Li,Michal Krawczyk,Dorota Skowronska-Krawczyk,Yujuan Wang,William Shi,Daniel Chen,Zheng Zhong,Zheng Zhong,Sheng Zhong,Liangfang Zhang,Shaochen Chen,Sean J. Morrison,Richard L. Maas,Kang Zhang,Yizhi Liu +43 more
TL;DR: This work designs a surgical method of cataract removal that preserves endogenous LECs and achieves functional lens regeneration in rabbits and macaques, as well as in human infants with cataracts, and provides a new paradigm for tissue regeneration using endogenous stem cells.
Journal ArticleDOI
P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma
Dorota Skowronska-Krawczyk,Ling Zhao,Ling Zhao,Jie Zhu,Jie Zhu,Robert N. Weinreb,Guiqun Cao,Jing Luo,Ken Flagg,Sherrina Patel,Cindy Wen,Martin Krupa,Hongrong Luo,Hong Ouyang,Hong Ouyang,Danni Lin,Wenqiu Wang,Wenqiu Wang,Gen Li,Yanxin Xu,Oulan Li,Christopher Chung,Emily Yeh,Maryam Jafari,Michael Ai,Zheng Zhong,William Shi,Lianghong Zheng,Michal Krawczyk,Daniel Chen,Catherine Shi,Carolyn Zin,Jin Zhu,Pamela L. Mellon,Weiwei Gao,Ruben Abagyan,Liangfang Zhang,Xiaodong Sun,Sheng Zhong,Yehong Zhuo,Michael G. Rosenfeld,Yizhi Liu,Kang Zhang +42 more
TL;DR: It is demonstrated that the genetic effect of the SIX6 risk variant is enhanced by another major POAG risk gene, p16INK4a, which leads to RGC senescence in adult human retinas, providing a unified theory of glaucoma pathogenesis.