P
Philippe Bonniaud
Researcher at French Institute of Health and Medical Research
Publications - 188
Citations - 7979
Philippe Bonniaud is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Medicine & Pulmonary fibrosis. The author has an hindex of 38, co-authored 151 publications receiving 6243 citations. Previous affiliations of Philippe Bonniaud include University of Burgundy & McMaster University.
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Journal ArticleDOI
Hsp27 negatively regulates cell death by interacting with cytochrome c
Jean-Marie Bruey,Cécile Ducasse,Philippe Bonniaud,Luigi Ravagnan,Santos A. Susin,Chantal Diaz-Latoud,Sandeep Gurbuxani,André-Patrick Arrigo,Guido Kroemer,Eric Solary,Carmen Garrido +10 more
TL;DR: Hsp27 binds to cytochrome c released from the mitochondria to the cytosol and prevents cy tochrome-c-mediated interaction of Apaf-1 with procaspase-9, which interferes specifically with the mitochondrial pathway of caspases-dependent cell death.
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Smad3 Null Mice Develop Airspace Enlargement and Are Resistant to TGF-β-Mediated Pulmonary Fibrosis
Philippe Bonniaud,Martin Kolb,Martin Kolb,Tom Galt,Jennifer Robertson,Clinton S. Robbins,Martin R. Stämpfli,Carol Lavery,Peter J. Margetts,Anita B. Roberts,Jack Gauldie +10 more
TL;DR: Basal activity of the pathway is required to maintain alveolar integrity and ECM homeostasis, but excessive signaling through the pathway results in fibrosis characterized by inhibited degradation and enhanced ECM deposition, suggesting a pivotal role of the Smad3 pathway in ECM metabolism.
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Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study.
Lionel Piroth,Jonathan Cottenet,Anne Sophie Mariet,Philippe Bonniaud,Mathieu Blot,Pascale Tubert-Bitter,Catherine Quantin +6 more
TL;DR: Patients admitted to hospital with COVID-19 more frequently developed acute respiratory failure, pulmonary embolism, septic shock, or haemorrhagic stroke than patients with influenza, but less frequently developed myocardial infarction or atrial fibrillation.
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Interstitial Lung Disease Induced by Drugs and Radiation
TL;DR: The diagnosis of drug-induced ILD (DI-ILD) essentially rests on the temporal association between exposure to the drug and the development of pulmonary infiltrates, and the histopathological features of DI-ILD are generally consistent, rather than suggestive or specific to thedrug etiology.
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Transient Overexpression of TGF-β1 Induces Epithelial Mesenchymal Transition in the Rodent Peritoneum
Peter J. Margetts,Philippe Bonniaud,Limin Liu,Catherine M. Hoff,Clifford J. Holmes,Judith A. West-Mays,Margaret M. Kelly +6 more
TL;DR: Findings suggest that EMT occurs in vivo after TGF-beta1 overexpression in the peritoneum and further supports the central role of T GF- beta1 in peritoneal fibrosis and provides an important model to study the sequence of events involved in TGF -beta1-induced EMT.