P
Philippe Bousso
Researcher at Pasteur Institute
Publications - 125
Citations - 9663
Philippe Bousso is an academic researcher from Pasteur Institute. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 43, co-authored 109 publications receiving 8685 citations. Previous affiliations of Philippe Bousso include University of California, Berkeley & French Institute of Health and Medical Research.
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Journal ArticleDOI
Enrichment of antigen-specific T lymphocytes by panning on immobilized MHC–peptide complexes
Philippe Bousso,Frédérique Michel,Nathalie Pardigon,Nadège Bercovici,Roland S. Liblau,Philippe Kourilsky,Jean-Pierre Abastado +6 more
TL;DR: A simple technique is described which allows enrichment in antigen-specific T lymphocytes among a heterogeneous CD8+ T cell population and takes advantage of peptide-specific adhesion induced by immobilized MHC-peptide complexes.
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TNF-Mediated toxicity after massive induction of specific CD8(+) T cells following immunization of mice with a tumor-specific peptide
Janine Bilsborough,Catherine Uyttenhove,Didier Colau,Philippe Bousso,Claude Libert,Birgit Weynand,Thierry Boon,Benoît Van den Eynde +7 more
TL;DR: It is concluded that the toxicity is caused by specific CD8+ lymphocytes, which are extensively amplified by peptide immunization in a QS21-based adjuvant and produce toxic levels of TNF upon further stimulation with the peptide.
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Manipulating leukocyte interactions in vivo through optogenetic chemokine release.
Milka Sarris,Romain Olekhnovitch,Romain Olekhnovitch,Romain Olekhnovitch,Philippe Bousso,Philippe Bousso +5 more
TL;DR: A versatile optogenetic method to control ligand secretion is introduced, combining UV-conditioned endoplasmic reticulum-to-Golgi trafficking and a furin-processing step, and it is demonstrated that a brief pulse of chemokine release can mediate a rapid flux of leukocyte contacts with target cells in vitro and in vivo.
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Facing Two T Cell Epitopes: A Degree of Randomness in the Primary Response Is Lost Upon Secondary Immunization
TL;DR: It is concluded that the CTL hierarchy is not controlled by the same parameters in a primary vs a secondary response to CD8 T cell response, at least for this set of epitopes.
Journal ArticleDOI
Real-time imaging of T-cell development.
TL;DR: Two-photon laser scanning microscopy has recently demonstrated great promise in tracking lymphocyte behavior in tissue environments and should help to clarify the mode of trafficking in the thymus and identify the spatio-temporal aspects of thymic selection events.