F
Fabrice Lemaître
Researcher at Pasteur Institute
Publications - 57
Citations - 3738
Fabrice Lemaître is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 29, co-authored 54 publications receiving 3263 citations. Previous affiliations of Fabrice Lemaître include French Institute of Health and Medical Research.
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Journal ArticleDOI
Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells.
Manuelle Viguier,Fabrice Lemaître,Olivier Verola,Min Sun Cho,Guy Gorochov,L. Dubertret,Hervé Bachelez,Philippe Kourilsky,Laurent Ferradini +8 more
TL;DR: It is found that CD4+CD25high T cells are overrepresented in metastatic lymph nodes (LNs) with a 2-fold increased frequency compared with both tumor-free LNs and autologous PBMCs, which could explain the poor clinical response of cancer patients under immunotherapeutic protocols.
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Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice
TL;DR: Real-time imaging of tumor cell apoptosis in vivo using intravital 2-photon microscopy and a Förster resonance energy transfer-based (FRET-based) reporter of caspase 3 activity offers new perspectives for understanding how immune effectors survey cancer cells and how local tumor microenvironments may subvert immune responses.
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Preexisting BCG-Specific T Cells Improve Intravesical Immunotherapy for Bladder Cancer
Claire Biot,Claire Biot,Claire Biot,Cyrill A. Rentsch,Cyrill A. Rentsch,Cyrill A. Rentsch,Joel R. Gsponer,Joel R. Gsponer,Joel R. Gsponer,Frédéric D. Birkhäuser,Hélène Jusforgues-Saklani,Hélène Jusforgues-Saklani,Fabrice Lemaître,Fabrice Lemaître,Charlotte Auriau,Charlotte Auriau,Alexander Bachmann,Philippe Bousso,Philippe Bousso,Caroline Demangel,Lucie Peduto,George N. Thalmann,Matthew L. Albert,Matthew L. Albert,Matthew L. Albert +24 more
TL;DR: New insight is provided into the mechanisms behind BCG’s success in the bladder and it is suggested that parenteral BCG exposure may boost the success rate for bladder cancer treatment, and monitoring patients’ response to purified protein derivative may provide a simple strategy that could improve therapeutic response.
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Real-Time Manipulation of T Cell-Dendritic Cell Interactions In Vivo Reveals the Importance of Prolonged Contacts for CD4+ T Cell Activation
TL;DR: The results establish the importance of prolonged T cell-DC interactions for efficient CD4(+) T cell activation in vivo and suggest that antigen availability on DCs regulates contact duration.
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Enumeration of human antigen–specific naive CD8+ T cells reveals conserved precursor frequencies
Cécile Alanio,Fabrice Lemaître,Fabrice Lemaître,Helen K. W. Law,Milena Hasan,Matthew L. Albert,Matthew L. Albert +6 more
TL;DR: Development of a procedure for direct assessment of T-cell precursor frequency in humans has important implications, with particular relevance to vaccine development and monitoring of tumor and self-reactive T cells.