Philippe Kastner

TL;DR: It appears that RXR gamma does not exert any essential function that cannot be performed by RXR alpha or RXR beta, and one copy of RXRalpha is sufficient to perform most of the functions of the RXRs.

TL;DR: A critical requirement of TLR9 in the process of MCMV sensing to assure rapid antiviral responses, coordinated with other TLR-dependent and -independent events that are sufficient to establish adaptive immunity are demonstrated.

TL;DR: Results demonstrate constitutive expression of RAR-gamma in human epidermis, and suggest that RAR -gamma is a molecular target of RA action in adult human skin.

TL;DR: It is shown that a precocious differentiation can be detected as early as 8.5 dpc in ventricular cardiomyocytes of RXRalpha(-/-) mutants, which indicates that retinoids are required at early stages of cardiac development to prevent differentiation, support cell proliferation and control the shape of ventricular myocytes, and both RXRs and RARs participate in the mediation of these functions.

TL;DR: A novel Ikaros‐targeted mouse line carrying a β‐galactosidase reporter in which low amounts of Ikaro proteins remain expressed shows that IkarOS controls multiple aspects of B cell differentiation and function.