P
Philippe Kastner
Researcher at University of Strasbourg
Publications - 118
Citations - 25684
Philippe Kastner is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Retinoic acid & Retinoid X receptor. The author has an hindex of 64, co-authored 117 publications receiving 24827 citations. Previous affiliations of Philippe Kastner include University of Michigan & French Institute of Health and Medical Research.
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Journal ArticleDOI
Ikaros Represses the Transcriptional Response to Notch Signaling in T-Cell Development
TL;DR: It is reported here that the Ikaros transcription factor plays a crucial role in repressing the transcriptional response to Notch signaling in T-cell development and functions as a transcriptional checkpoint to repress Notch target gene expression in T cells.
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Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity.
TL;DR: The results show that the lifespan of adult hepatocytes lacking RXRα is shorter than that of their wild-type counterparts, whereas proliferative hepatocytes of regenerating liver exhibit an even shorter lifespan.
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Ikaros regulates neutrophil differentiation
TL;DR: It is shown that Ikaros regulates early neutrophil differentiation but is dispensable in mature neutrophils, and furthermore Ik(L/L) mice, harboring a hypomorphic mutation at the Ikaro locus, exhibit several defects during neutrophIL differentiation.
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Ikaros controls isotype selection during immunoglobulin class switch recombination
TL;DR: Results reveal transcriptional competition between constant region genes in individual cells to be a critical and general mechanism for isotype specification during CSR and show that Ikaros is a master regulator of this competition.
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Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia
C Virely,S Moulin,S Moulin,S Moulin,César Cobaleda,C Lasgi,C Lasgi,C Lasgi,A Alberdi,A Alberdi,J Soulier,J Soulier,F Sigaux,F Sigaux,Susan Chan,Philippe Kastner,Jacques Ghysdael,Jacques Ghysdael,Jacques Ghysdael +18 more
TL;DR: Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia.