P
Philippe Lesavre
Researcher at Necker-Enfants Malades Hospital
Publications - 89
Citations - 9129
Philippe Lesavre is an academic researcher from Necker-Enfants Malades Hospital. The author has contributed to research in topics: Proteinase 3 & Anti-neutrophil cytoplasmic antibody. The author has an hindex of 35, co-authored 89 publications receiving 8447 citations. Previous affiliations of Philippe Lesavre include University of Paris & Paris Descartes University.
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Journal ArticleDOI
Efficiency of curative and prophylactic treatment with rituximab in ADAMTS13-deficient thrombotic thrombocytopenic purpura: a study of 11 cases
Fadi Fakhouri,Jean Paul Vernant,Agnès Veyradier,Martine Wolf,Gilles Kaplanski,Raynald Binaut,Manfred Rieger,Friedrich Scheiflinger,Pascale Poullin,Benjamin Deroure,Richard Delarue,Philippe Lesavre,Philippe Vanhille,Olivier Hermine,Giuseppe Remuzzi,Jean Pierre Grunfeld +15 more
TL;DR: Rituximab is a promising first-line immunosuppressive treatment in patients with acute refractory and severe relapsing TTP related to anti-ADAMTS13 antibodies.
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A Large Subset of Neutrophils Expressing Membrane Proteinase 3 Is a Risk Factor for Vasculitis and Rheumatoid Arthritis
Véronique Witko-Sarsat,Philippe Lesavre,S. Lopez,Gilles Bessou,Corinne Hieblot,Bernard Prum,Laure Hélène Noël,Loïc Guillevin,Philippe Ravaud,Isabelle Sermet-Gaudelus,José Timsit,Jean-Pierre Grünfeld,Lise Halbwachs-Mecarelli +12 more
TL;DR: The frequency of the mPR3high phenotype was significantly increased in patients with ANCA-associated vasculitis and was normal in type I-diabetes, a T cell-dependent autoimmune disease.
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Alpha1-antitrypsin genetic polymorphism in ANCA-positive systemic vasculitis
Vincent L.M. Esnault,Angelo Testa,Marie A. P. Audrain,Christophe Rogé,Mohamed Hamidou,Jacques H. Barrier,Richard Sesboüé,Jean-Pierre Martin,Philippe Lesavre +8 more
TL;DR: The association of severely and medium deficient PI phenotypes with anti-PR3 positive systemic vasculitis, and postulate a pathogenetic role for alpha 1-AT deficiency and the occurrence of ANCA are described.
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Complement alternative pathway acts as a positive feedback amplification of neutrophil activation.
Laurent Camous,Lubka T. Roumenina,Sylvain Bigot,Soumeya Brachemi,Véronique Frémeaux-Bacchi,Philippe Lesavre,Lise Halbwachs-Mecarelli +6 more
TL;DR: It is shown that neutrophils themselves activate complement when stimulated by cytokines or coagulation-derived factors, which triggers a new amplification loop in physiologic innate immunity: Neutrophils activate the alternative complement pathway and release C5 fragments, which further amplify neutrophil proinflammatory responses.
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H deficiency in two brothers with atypical dense intramembranous deposit disease.
Micheline Levy,Lise Halbwachs–Mecarelli,Marie Claire Gubler,Gérard Kohout,Abdelatif Bensenouci,Patrick Niaudet,Georges Hauptmann,Philippe Lesavre +7 more
TL;DR: Renal biopsies from two Algerian brothers who had early-onset glomerulonephritis showed an atypical pattern with abundant granular C3 deposits within the mesangium and along the capillary walls, which may represent an interesting clue to the relationship between nephritic factor, alternative pathway activation, and dense intramembranous deposit disease.