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Phillip D. Markham
Researcher at Litton Industries
Publications - 96
Citations - 11962
Phillip D. Markham is an academic researcher from Litton Industries. The author has contributed to research in topics: Virus & Simian immunodeficiency virus. The author has an hindex of 50, co-authored 95 publications receiving 11825 citations.
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Journal ArticleDOI
Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6.
Paolo Lusso,Barbara Ensoli,Phillip D. Markham,Dharam V. Ablashi,S. Zaki Salahuddin,Erwin Tschachler,Flossie Wong-Staal,Robert C. Gallo +7 more
TL;DR: It is demonstrated that HHV-6 and HIV-1 can productively co-infect individual human CD4+ T lymphocytes, resulting in accelerated HIV- 1 expression and cellular death, and evidence that HHv-6 transactivates the HIV-2 long terminal repeat (LTR) is presented.
Journal ArticleDOI
The Acquired Immunodeficiency Syndrome: An Update
TL;DR: The acquired immunodeficiency syndrome continues to be a major public health problem in the United States, and recently its spread worldwide has accelerated.
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Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques.
Igor M. Belyakov,Zdenek Hel,Brian L. Kelsall,Vladimir A. Kuznetsov,Jeffrey D. Ahlers,Janos Nacsa,David I. Watkins,Todd M. Allen,Alessandro Sette,John D. Altman,Ruth A. Woodward,Phillip D. Markham,John D. Clements,Genoveffa Franchini,Warren Strober,Jay A. Berzofsky +15 more
TL;DR: Induction of CTLs in the intestinal mucosa, a key site of virus replication, with a mucosal AIDS vaccine ameliorates infection by SHIV in non-human primates.
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Genomic diversity of human T-lymphotropic virus type III (HTLV-III).
Flossie Wong-Staal,George M. Shaw,Beatrice H. Hahn,Saira Salahuddin,Mikulas Popovic,Phillip D. Markham,Robert R. Redfield,Robert C. Gallo +7 more
TL;DR: It is indicated that different isolates of HTLV-III comprise a spectrum of highly related but distinguishable viruses and have important implications regarding the pathogenicity of HT LV-III and attempts to develop effective diagnostic, therapeutic, and preventive measures for this virus.
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Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages.
Marjorie Robert-Guroff,Mikulas Popovic,Suzanne Gartner,Phillip D. Markham,Robert C. Gallo,Marvin S. Reitz +5 more
TL;DR: It appears that different cell types infected with different strains of HIV-1 maintain a similar balance of expression in which transcripts for nef vastly predominate over those for tat and that those for rev are intermediate in abundance.