Phillip D. Markham

TL;DR: It is shown that both large and small vessel endothelial cells chronically exposed to inflammatory cytokines produce and release bioactive bFGF in the absence of cell death, and a mechanism by which these cytokines can cooperate in the induction of KS is suggested.

TL;DR: It is demonstrated that HTLV isolated from T‐cell leukemic donors from different parts of the world can productively infect and transform fresh human cord blood T‐lymphocytes, and that the transformed cells share many similarities with fresh or cultured leukedmic cells.

TL;DR: Priming with DNA encoding Env antigens from multiple HIV-1 clades followed by boosting with homologous Env proteins elicits anti-HIV-1 immune responses capable of protecting macaques against mucosal transmission of R5 tropic SHIV isolate.

TL;DR: The results indicate that improved gene delivery and expression by electroporation dramatically increases immunogenicity of DNA vaccines and is thus an important method to improve the effectiveness of DNA vaccination.

TL;DR: In conclusion, immunization with MVA/SHIV89.6 alone or with a protein boost stimulated both arms of the immune system and resulted in significant control of viremia and delayed progression to disease after challenge with SHIV- 89.6P.