J
John D. Clements
Researcher at Tulane University
Publications - 108
Citations - 6469
John D. Clements is an academic researcher from Tulane University. The author has contributed to research in topics: Adjuvant & Antigen. The author has an hindex of 44, co-authored 108 publications receiving 6049 citations. Previous affiliations of John D. Clements include Texas A&M University & University of Rochester.
Papers
More filters
Journal ArticleDOI
Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato.
Carol O. Tacket,Hugh S. Mason,Genevieve Losonsky,John D. Clements,Myron M. Levine,Charles J. Arntzen +5 more
TL;DR: The present study was conducted as a proof of principle to determine if humans would also develop a serum and/or mucosal immune response to an antigen delivered in an uncooked foodstuff.
Journal ArticleDOI
Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene.
TL;DR: Findings show that an edible vaccine against E. coli LT-B is feasible and demonstrates immunogenicity by feeding mice the raw tubers and comparing the anti-LT-B serum IgG and faecal IgA to that produced in mice gavaged with bacterial LT- B.
Journal ArticleDOI
Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques.
Igor M. Belyakov,Zdenek Hel,Brian L. Kelsall,Vladimir A. Kuznetsov,Jeffrey D. Ahlers,Janos Nacsa,David I. Watkins,Todd M. Allen,Alessandro Sette,John D. Altman,Ruth A. Woodward,Phillip D. Markham,John D. Clements,Genoveffa Franchini,Warren Strober,Jay A. Berzofsky +15 more
TL;DR: Induction of CTLs in the intestinal mucosa, a key site of virus replication, with a mucosal AIDS vaccine ameliorates infection by SHIV in non-human primates.
Journal ArticleDOI
Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis.
TL;DR: This is the first report to demonstrate that MMPs contribute to the development of neuronal injury in bacterial meningitis and that inhibition of M MPs may be an effective approach to prevent brain damage as a consequence of the disease.
Journal ArticleDOI
Characterization of a Mutant Escherichia coli Heat-Labile Toxin, LT(R192G/L211A), as a Safe and Effective Oral Adjuvant
TL;DR: dmLT is a safe and powerful detoxified enterotoxin with the potential to function as a mucosal adjuvant for coadministered antigens and to elicit anti-LT antibodies without undesirable side effects.