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Phillip L. Lowrey
Researcher at Northwestern University
Publications - 11
Citations - 7829
Phillip L. Lowrey is an academic researcher from Northwestern University. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 11, co-authored 11 publications receiving 7307 citations. Previous affiliations of Phillip L. Lowrey include Howard Hughes Medical Institute & Rider University.
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Journal ArticleDOI
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
Seung Hee Yoo,Shin Yamazaki,Shin Yamazaki,Phillip L. Lowrey,Kazuhiro Shimomura,Caroline H. Ko,Caroline H. Ko,Ethan D. Buhr,Sandra M. Siepka,Hee Kyung Hong,Won Jun Oh,Ook Joon Yoo,Michael Menaker,Joseph S. Takahashi +13 more
TL;DR: It is demonstrated that peripheral tissues express self-sustained, rather than damped, circadian oscillations and the existence of organ-specific synchronizers of circadian rhythms at the cell and tissue level is suggested.
Journal ArticleDOI
Mutagenesis and Mapping of a Mouse Gene, Clock, Essential for Circadian Behavior
Martha Hotz Vitaterna,David P. King,Anne Marie Chang,Jon M. Kornhauser,Phillip L. Lowrey,J. David McDonald,J. David McDonald,William F. Dove,Lawrence H. Pinto,Fred W. Turek,Joseph S. Takahashi +10 more
TL;DR: The power of ENU mutagenesis combined with the ability to clone murine genes by map position provides a generally applicable approach to study complex behavior in mammals.
Journal ArticleDOI
Positional cloning of the mouse circadian clock gene.
David P. King,Yaliang Zhao,Ashvin M. Sangoram,Lisa D. Wilsbacher,Minoru Tanaka,Marina P. Antoch,Thomas D.L. Steeves,Martha Hotz Vitaterna,Jon M. Kornhauser,Jon M. Kornhauser,Phillip L. Lowrey,Fred W. Turek,Joseph S. Takahashi +12 more
TL;DR: CLOCK represents the second example of a PAS domain-containing clock protein (besides Drosophila PERIOD), which suggests that this motif may define an evolutionarily conserved feature of the circadian clock mechanism.
Journal ArticleDOI
Mammalian circadian biology: elucidating genome-wide levels of temporal organization.
TL;DR: The importance of maintaining the internal temporal homeostasis conferred by the circadian system is revealed by animal models in which mutations in genes coding for core components of the clock result in disease, including cancer and disturbances to the sleep/wake cycle.
Journal ArticleDOI
Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau
Phillip L. Lowrey,Kazuhiro Shimomura,Marina P. Antoch,Shin Yamazaki,Peter D. Zemenides,Martin R. Ralph,Michael Menaker,Joseph S. Takahashi +7 more
TL;DR: The tau mutation is a semidominant autosomal allele that dramatically shortens period length of circadian rhythms in Syrian hamsters and the mechanism by which the mutation leads to the observed aberrant circadian phenotype in mutant animals is proposed.