Phuong-Hien Nguyen

TL;DR: Targeted deletion of the gene for macrophage migration inhibitory factor delays development of chronic lymphocytic leukemia and prolongs survival in mice and provides evidence that MIF supports the development of CLL by enhancing the interaction of Coll cells with macrophages.

TL;DR: It is demonstrated that LYN kinase is essential for CLL progression and syngeneic CLL transplantation of CLL cells into Lyn- or Btk-deficient recipients results in a strongly delayed leukemic progression and prolonged survival.

TL;DR: Two aggressive CLL models are generated and the authors provide a preclinical rational for the use of PARP inhibitors in ATM-affected human CLL and show that Atm-deficient CLL is sensitive to PARP1 inhibition.

TL;DR: The evidence for BAK inhibitors being part of a class of agents that modulate the (hematopoietic) microenvironment of cancers is summarized and validates.

TL;DR: The validation of the polycationic phosphorus dendrimer-based approach for small interfering RNAs delivery in in vitro stem-like cells as models shows that anti-Lyn siRNA, delivered into Lyn-expressing glioma cell model reduces the cell viability, a fact that was not observed in a cell model that lacks Lyn-expression.