P
Pier Luigi Canonico
Researcher at University of Eastern Piedmont
Publications - 60
Citations - 3158
Pier Luigi Canonico is an academic researcher from University of Eastern Piedmont. The author has contributed to research in topics: Click chemistry & Neuroprotection. The author has an hindex of 27, co-authored 60 publications receiving 2771 citations.
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Journal ArticleDOI
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes.
Gian Cesare Tron,Tracey Pirali,Richard A. Billington,Pier Luigi Canonico,Giovanni Sorba,Armando A. Genazzani +5 more
TL;DR: The present review will outline the accomplishments of the 1,3‐dipolar cycloaddition (“click‐reaction”) between azides and alkynes catalyzed by copper (I) salts and outline some of medicinal chemistry applications in which click‐chemistry might be relevant in the future.
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The other face of depression, reduced positive affect : the role of catecholamines in causation and cure
David J. Nutt,Koen Demyttenaere,Zoltán Janka,Trond Aarre,Michel Bourin,Pier Luigi Canonico,José L. Carrasco,Steven Stahl +7 more
TL;DR: There is evidence to suggest that antidepressants that enhance noradrenergic and dopaminergic activity may afford a therapeutic advantage over serotonergic antidepressants in the treatment of symptoms associated with a reduction in positive affect.
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Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB.
Dmitry Lim,Anand Iyer,Virginia Ronco,Ambra A. Grolla,Pier Luigi Canonico,Eleonora Aronica,Armando A. Genazzani +6 more
TL;DR: The data suggest that nanomolar [Aβ] deregulates Ca2+ homeostasis via CaN and its downstream target NF‐kB, possibly via the cross‐talk of Bcl10 in hippocampal astrocytes.
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DPYD IVS14+1G>A and 2846A>T genotyping for the prediction of severe fluoropyrimidine-related toxicity: a meta-analysis.
Salvatore Terrazzino,Sarah Cargnin,Marzia Del Re,Romano Danesi,Pier Luigi Canonico,Armando A. Genazzani +5 more
TL;DR: Clinical validity of DPYD IVS14+1G>A and 2846A>T as risk factors for the development of severe toxicities following fluoropyrimidine treatment is confirmed and the sensitivity and specificity estimates obtained could be useful in establishing the cost-effectiveness of testing for DPYD variants.
Journal ArticleDOI
Glia Mediates the Neuroprotective Action of Estradiol on β-Amyloid-Induced Neuronal Death
Maria Angela Sortino,Mariangela Chisari,Sara Merlo,Carlo Vancheri,Massimo Caruso,Ferdinando Nicoletti,Pier Luigi Canonico,Agata Copani +7 more
TL;DR: In support of a role for TGF- beta1 in astrocyte-mediated 17beta-E(2) neuroprotective activity, incubation with a neutralizing anti-TGF-beta1 antibody significantly modified the reduction of neuronal death induced by 17 beta-E (2)-treated astroCyte-conditioned medium.