Massimo Caruso

TL;DR: In smokers not intending to quit, the use of e-cigarettes, with or without nicotine, decreased cigarette consumption and elicited enduring tobacco abstinence without causing significant side effects.

TL;DR: U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment, and is well suited to identify asthma phenotypes using the array of "omic" datasets that are at the core of this systems medicine approach.

TL;DR: Clustering based on clinicophysiologic parameters yielded 4 stable and reproducible clusters of asthmatic patients that associate with different pathobiological pathways.

TL;DR: It is indicated that regular use of e-cigs to substitute smoking is associated with objective and subjective improvements in asthma outcomes, and shows that e-Cigs can be a valid option for asthmatic patients who cannot quit smoking by other methods.

TL;DR: It is concluded that smokers who reduce or quit smoking by switching to e-cigarettes may lower their systolic BP in the long term, and this reduction is apparent in smokers with elevated BP.