P
Pierre Eid
Researcher at French Institute of Health and Medical Research
Publications - 56
Citations - 2646
Pierre Eid is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Interferon & Receptor. The author has an hindex of 24, co-authored 56 publications receiving 2445 citations. Previous affiliations of Pierre Eid include University of Paris-Sud & University of Paris.
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Journal ArticleDOI
Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency.
Stéphanie Dupuis,Emmanuelle Jouanguy,Sami Al-Hajjar,Claire Fieschi,Ibrahim Al-Mohsen,Suliman Al-Jumaah,Kun Yang,Ariane Chapgier,Celine Eidenschenk,Pierre Eid,Abdulaziz Al Ghonaium,Haysam Tufenkeji,Husn H. Frayha,Suleiman Al-Gazlan,Hassan Al-Rayes,Robert D. Schreiber,Ion Gresser,Jean-Laurent Casanova,Jean-Laurent Casanova +18 more
TL;DR: Two unrelated infants homozygous with respect to mutated STAT1 alleles are reported, both infants suffered from mycobacterial disease, but unlike individuals with IFN-γR deficiency, both died of viral disease.
Journal ArticleDOI
T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-β†
Luca Durelli,Laura Conti,Marinella Clerico,Daniela Boselli,Giulia Contessa,P. Ripellino,B. Ferrero,Pierre Eid,Francesco Novelli +8 more
TL;DR: The Th1/Th17 cell populations in peripheral blood, their interferon (IFN) receptor expression sensitivity to IFN‐β in MS patients is characterized.
Journal ArticleDOI
The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.
TL;DR: It is reported that Tyk2 is essential for stable cell surface expression of IFNAR1 and that this function is distinct from the previously reported effect of other Jak proteins on receptor exit from the endoplasmic reticulum.
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Viruses induce high expression of BAFF by salivary gland epithelial cells through TLR- and type-I IFN-dependent and -independent pathways.
Marc Ittah,Corinne Miceli-Richard,Jacques-Eric Gottenberg,Jérémie Sellam,Pierre Eid,Pierre Lebon,Coralie Pallier,Christine Lepajolec,Xavier Mariette +8 more
TL;DR: BAFF induction by target organs of autoimmune diseases after viral infection may be a link between innate immunity and autoimmunity.
Journal ArticleDOI
Stat-mediated Signaling Induced by Type I and Type II Interferons (IFNs) Is Differentially Controlled through Lipid Microdomain Association and Clathrin-dependent Endocytosis of IFN Receptors
Marta Marchetti,Marie-Noëlle Monier,Alexandre Fradagrada,Keith Mitchell,Florence Baychelier,Pierre Eid,Ludger Johannes,Christophe Lamaze +7 more
TL;DR: It is concluded that IFN-R compartmentalization at the plasma membrane plays a critical role in the signaling and biological responses induced by IFNs and contributes to establishing specificity within the Jak/Stat signaling pathway.