K
Kun Yang
Researcher at University of Paris
Publications - 17
Citations - 3431
Kun Yang is an academic researcher from University of Paris. The author has contributed to research in topics: Immunity & Interferon gamma. The author has an hindex of 14, co-authored 14 publications receiving 3186 citations. Previous affiliations of Kun Yang include Shanghai Jiao Tong University & Paris Descartes University.
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Journal ArticleDOI
Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency.
Stéphanie Dupuis,Emmanuelle Jouanguy,Sami Al-Hajjar,Claire Fieschi,Ibrahim Al-Mohsen,Suliman Al-Jumaah,Kun Yang,Ariane Chapgier,Celine Eidenschenk,Pierre Eid,Abdulaziz Al Ghonaium,Haysam Tufenkeji,Husn H. Frayha,Suleiman Al-Gazlan,Hassan Al-Rayes,Robert D. Schreiber,Ion Gresser,Jean-Laurent Casanova,Jean-Laurent Casanova +18 more
TL;DR: Two unrelated infants homozygous with respect to mutated STAT1 alleles are reported, both infants suffered from mycobacterial disease, but unlike individuals with IFN-γR deficiency, both died of viral disease.
Journal ArticleDOI
Herpes simplex virus encephalitis in human UNC-93B deficiency.
Armanda Casrouge,Shen-Ying Zhang,Shen-Ying Zhang,Celine Eidenschenk,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Anne Puel,Kun Yang,Kun Yang,Alexandre Alcaïs,Capucine Picard,Nora Mahfoufi,Nathalie Nicolas,Lazaro Lorenzo,Sabine Plancoulaine,Brigitte Senechal,Frederic Geissmann,Koichi Tabeta,Koichi Tabeta,Kasper Hoebe,Xin Du,Richard L. Miller,Bénédicte Héron,Cyril Mignot,Thierry Billette de Villemeur,Pierre Lebon,Olivier Dulac,Flore Rozenberg,Bruce Beutler,Marc Tardieu,Laurent Abel,Jean-Laurent Casanova,Jean-Laurent Casanova +32 more
TL;DR: A genetic etiology for HSE is elucidated in two children with autosomal recessive deficiency in the intracellular protein UNC-93B, resulting in impaired cellular interferon-α/β and -λ antiviral responses.
Journal ArticleDOI
Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity
Cheng-Lung Ku,Horst von Bernuth,Horst von Bernuth,Capucine Picard,Shen-Ying Zhang,Huey Hsuan Chang,Kun Yang,Maya Chrabieh,Andrew C. Issekutz,Coleen K. Cunningham,John I. Gallin,Steven M. Holland,Chaim M. Roifman,Stephan Ehl,Joanne Smart,Mimi L.K. Tang,Franck J. Barrat,Ofer Levy,Douglas R. McDonald,Noorbibi K. Day-Good,Richard L. Miller,Hidetoshi Takada,Toshiro Hara,Sami Al-Hajjar,Abdulaziz Al-Ghonaium,David P. Speert,Damien Sanlaville,Xiaoxia Li,Frederic Geissmann,Eric Vivier,László Maródi,Ben Zion Garty,Helen Chapel,Carlos Rodríguez-Gallego,Xavier Bossuyt,Laurent Abel,Anne Puel,Jean-Laurent Casanova +37 more
TL;DR: The IRAK-4–dependent TLRs and IL-1Rs are therefore vital for childhood immunity to pyogenic bacteria, particularly Streptococcus pneumoniae, and appear to play a redundant role in protective immunity to most infections.
Journal ArticleDOI
Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense.
Shen-Ying Zhang,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Ariane Chapgier,Ariane Chapgier,Kun Yang,Kun Yang,Jacinta Bustamante,Jacinta Bustamante,Anne Puel,Anne Puel,Capucine Picard,Capucine Picard,Laurent Abel,Laurent Abel,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Jean-Laurent Casanova +18 more
TL;DR: These experiments of nature suggest that the three types of IFNs play at least two different roles in host defense, whereas IFN‐γ is essential for anti‐mycobacterial immunity, whereasIFN‐α/β and IFn‐λ are essential forAnti‐viral immunity.
Journal ArticleDOI
Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses
Kun Yang,Kun Yang,Anne Puel,Shen-Ying Zhang,Shen-Ying Zhang,Celine Eidenschenk,Cheng-Lung Ku,Armanda Casrouge,Capucine Picard,Capucine Picard,Horst von Bernuth,Brigitte Senechal,Sabine Plancoulaine,Sami Al-Hajjar,Abdulaziz Al-Ghonaium,László Maródi,Donald J. Davidson,David P. Speert,Chaim M. Roifman,Ben Zion Garty,Adrian Ozinsky,Franck J. Barrat,Robert L. Coffman,Richard L. Miller,Xiaoxia Li,Pierre Lebon,Carlos Rodríguez-Gallego,Helen Chapel,Frederic Geissmann,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Jean-Laurent Casanova,Jean-Laurent Casanova,Jean-Laurent Casanova +33 more
TL;DR: It is shown here that IFN-α/β and -λ induction via TLR-7, TLr-8, andTLR-9-dependent induction was abolished in IRAK-4-deficient blood cells, indicating patients with a defect of IRAk-4 are resistant to common viruses.