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Pierre Olivier Couraud
Researcher at Paris Descartes University
Publications - 35
Citations - 2669
Pierre Olivier Couraud is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Endothelial stem cell & Blood–brain barrier. The author has an hindex of 23, co-authored 35 publications receiving 2296 citations. Previous affiliations of Pierre Olivier Couraud include Cornell University & University of Paris.
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Journal ArticleDOI
In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use
Hans Christian Cederberg Helms,N. Joan Abbott,Malgorzata Burek,Roméo Cecchelli,Pierre Olivier Couraud,Mária A. Deli,Carola Förster,H.-J. Galla,Ignacio A. Romero,Eric V. Shusta,Matthew J. Stebbins,Elodie Vandenhaute,Babette B. Weksler,Birger Brodin +13 more
TL;DR: A review of established in vitro blood-brain barrier models with a focus on their validation regarding a set of well-established bloodbrain barrier characteristics is given in this paper, with an overview of the advantages and drawbacks of the different models described.
Journal ArticleDOI
Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier
Nicola F. Fletcher,Garrick K. Wilson,Jacinta Murray,Ke Hu,Andrew L. Lewis,Gary M. Reynolds,Zania Stamataki,Luke W. Meredith,Ian A. Rowe,Guangxiang Luo,Miguel A. Lopez–Ramirez,Thomas F. Baumert,Babette B. Weksler,Pierre Olivier Couraud,Kwang Sik Kim,Ignacio A. Romero,Catherine L. Jopling,Susan Morgello,Peter Balfe,Jane A. McKeating +19 more
TL;DR: Human brain endothelial cells express functional receptors that support HCV entry and replication, and virus infection of the CNS might lead to HCV-associated neuropathologies.
Journal ArticleDOI
Methamphetamine disrupts blood–brain barrier function by induction of oxidative stress in brain endothelial cells
Servio H. Ramirez,Raghava Potula,Shongshan Fan,Tess M. Eidem,Anil Papugani,Nancy L. Reichenbach,Holly Dykstra,Babette B. Weksler,Ignacio A. Romero,Ignacio A. Romero,Pierre Olivier Couraud,Yuri Persidsky +11 more
TL;DR: It is reported that METH increases BBB permeability in vivo, and exposure of primary human brain microvascular endothelial cells (BMVEC) to METH diminishes the tightness of BMVEC monolayers in a dose- and time-dependent manner by decreasing the expression of cell membrane-associated tight junction (TJ) proteins.
Journal ArticleDOI
Identification of an essential endogenous regulator of blood–brain barrier integrity, and its pathological and therapeutic implications
Enrico Cristante,Simon McArthur,Claudio Mauro,Elisa Maggioli,Ignacio A. Romero,Marzena Wylezinska-Arridge,Pierre Olivier Couraud,Jordi Lopez-Tremoleda,Helen C. Christian,Babette B. Weksler,Andrea Malaspina,Egle Solito +11 more
TL;DR: It is proposed that the glucocorticoid anti-inflammatory messenger annexin A1 (ANXA1) is expressed in brain microvascular endothelial cells, where it regulates BBB integrity and may have utility in the treatment of MS, correcting BBB function and hence ameliorating disease.
Journal ArticleDOI
Activation of β-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells
Joseph C Lim,Katarzyna D. Kania,Katarzyna D. Kania,Hasini C. Wijesuriya,Sangeeta Chawla,Jaswinder K. Sethi,Lukasz Pulaski,Ignacio A. Romero,Pierre Olivier Couraud,Babette B. Weksler,Stephen B. Hladky,Margery A. Barrand +11 more
TL;DR: Results suggest that regulation of p‐gp and other multidrug efflux transporters in brain vasculature can be influenced by β‐catenin signalling.