P
Pietro De Camilli
Researcher at Yale University
Publications - 338
Citations - 51433
Pietro De Camilli is an academic researcher from Yale University. The author has contributed to research in topics: Endocytic cycle & Dynamin. The author has an hindex of 120, co-authored 318 publications receiving 47033 citations. Previous affiliations of Pietro De Camilli include Osaka University & Harvard University.
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Journal ArticleDOI
Phosphoinositides in cell regulation and membrane dynamics
TL;DR: Inositol phospholipids mediate acute responses, but also act as constitutive signals that help define organelle identity, and play a fundamental part in controlling membrane–cytosol interfaces.
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Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase.
Steinunn Baekkeskov,Henk-Jan Aanstoot,Stephan Christgai,Annette Reetz,Michele Solimena,Marilia Cascalho,Franco Folli,Hanne Richter-Olesen,Pietro De Camilli +8 more
TL;DR: The pancreatic islet β-cell autoantigen of relative molecular mass 64,000 (64K), which is a major target of autoantibodies associated with the development of insulin-dependent diabetes mel-litus (IDDM), has been identified as glutamic acid decarboxylase, the biosynthesizing enzyme of the inhibitory neurotransmitter GABA.
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The BioPlex Network: A Systematic Exploration of the Human Interactome
Edward L. Huttlin,Lily Ting,Raphael J. Bruckner,Fana Gebreab,Melanie P. Gygi,John Szpyt,Stanley Tam,Gabriela Zarraga,Greg Colby,Kurt Baltier,Rui Dong,Virginia Guarani,Laura Pontano Vaites,Alban Ordureau,Ramin Rad,Brian K. Erickson,Martin Wühr,Joel M. Chick,Bo Zhai,Deepak Kolippakkam,Julian Mintseris,Robert A. Obar,Robert A. Obar,Tim Harris,Spyros Artavanis-Tsakonas,Spyros Artavanis-Tsakonas,Mathew E. Sowa,Pietro De Camilli,Joao A. Paulo,J. Wade Harper,Steven P. Gygi +30 more
TL;DR: Using high-throughput affinity-purification mass spectrometry, BioPlex is used to identify interacting partners for 2,594 human proteins in HEK293T cells and reveals associations among thousands of protein domains, suggesting a basis for examining structurally related proteins.
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Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
Juan Blasi,Juan Blasi,Edwin R. Chapman,E. Link,Thomas Binz,S. Yamasaki,Pietro De Camilli,Thomas C. Südhof,Heiner Niemann,Reinhard Jahn +9 more
TL;DR: It is demonstrated that BoNT/A acts as a zinc-dependent protease that selectively cleaves SNAP-25, a second component of the putative fusion complex mediating synaptic vesicle exocytosis is targeted by a clostridial neurotoxin.
Journal ArticleDOI
Erratum: Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase (Nature (1990) 347 (151-156))
Steinunn Baekkeskov,Henk-Jan Aanstoot,Stephan Christgau,Annette Reetz,Michele Solimena,Marilia Cascalho,Franco Folli,Hanne Richter-Oleson,Pietro De Camilli +8 more
TL;DR: In the published version of this article, the name of one of the authors (P. De C.) was incorrectly hyphenated.