M
Michele Solimena
Researcher at Dresden University of Technology
Publications - 191
Citations - 12757
Michele Solimena is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Insulin & Granule (cell biology). The author has an hindex of 50, co-authored 175 publications receiving 11195 citations. Previous affiliations of Michele Solimena include University of California & Yale University.
Papers
More filters
Journal ArticleDOI
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase.
Steinunn Baekkeskov,Henk-Jan Aanstoot,Stephan Christgai,Annette Reetz,Michele Solimena,Marilia Cascalho,Franco Folli,Hanne Richter-Olesen,Pietro De Camilli +8 more
TL;DR: The pancreatic islet β-cell autoantigen of relative molecular mass 64,000 (64K), which is a major target of autoantibodies associated with the development of insulin-dependent diabetes mel-litus (IDDM), has been identified as glutamic acid decarboxylase, the biosynthesizing enzyme of the inhibitory neurotransmitter GABA.
Journal ArticleDOI
Erratum: Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase (Nature (1990) 347 (151-156))
Steinunn Baekkeskov,Henk-Jan Aanstoot,Stephan Christgau,Annette Reetz,Michele Solimena,Marilia Cascalho,Franco Folli,Hanne Richter-Oleson,Pietro De Camilli +8 more
TL;DR: In the published version of this article, the name of one of the authors (P. De C.) was incorrectly hyphenated.
Journal ArticleDOI
Content-aware image restoration: pushing the limits of fluorescence microscopy.
Martin Weigert,Uwe Schmidt,Tobias Boothe,Andreas Müller,Alexandr Dibrov,Akanksha Jain,Benjamin Wilhelm,Deborah Schmidt,Coleman Broaddus,Siân Culley,Siân Culley,Mauricio Rocha-Martins,Fabián Segovia-Miranda,Caren Norden,Ricardo Henriques,Ricardo Henriques,Marino Zerial,Michele Solimena,Jochen C. Rink,Pavel Tomancak,Loic Royer,Florian Jug,Eugene W. Myers,Eugene W. Myers +23 more
TL;DR: This work shows how content-aware image restoration based on deep learning extends the range of biological phenomena observable by microscopy by bypassing the trade-offs between imaging speed, resolution, and maximal light exposure that limit fluorescence imaging to enable discovery.
Journal ArticleDOI
Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome.
TL;DR: The hypothesis that stiff-man syndrome is an autoimmune disease is supported and GAD is suggested to be the primary autoantigen involved in stiff- man syndrome and the associated insulin-dependent diabetes mellitus is suggested.
Journal ArticleDOI
Autoantibodies to Glutamic Acid Decarboxylase in a Patient with Stiff-Man Syndrome, Epilepsy, and Type I Diabetes Mellitus
Michele Solimena,Franco Folli,S. Denis-Donini,Giancarlo Comi,Guido Pozza,P De Camilli,Aurelio M. Vicari +6 more
TL;DR: The findings support the idea that an impairment of neuronal pathways that operate through gamma-aminobutyric acid is involved in the pathogenesis of stiff-man syndrome, and they raise the possibility of an autoimmune pathogenesis.