Prabhakar S. Andhey

TL;DR: Single-nucleus RNA sequencing in a mouse model of Aβ accumulation and postmortem brain tissue from people with Alzheimer’s disease reveals substantial species-specific differences in transcriptional signatures, but both point to the contribution of glia and the importance of TREM2.

TL;DR: This work defined organ-specific and common immune alterations and identified a subpopulation of age-associated granzyme K-expressing CD8+ T (Taa) cells that are distinct from T effector memory (Tem) cells, a potential target to address age- associated dysfunctions of the immune system.

TL;DR: Itaconate is established as an immunoregulatory, rather than strictly immunosuppressive, metabolite and highlights the importance of using unmodified itaconate in future studies, as well as identifying a new regulatory mode of inhibiting IL-1β secretion and enhancing IFN-β signalling.

TL;DR: In the brain, apoE is produced and secreted primarily by astrocytes and activated microglia as discussed by the authors, which is the strongest genetic risk factor for Alzheimer's disease.

TL;DR: Toxoplasma gondii infection converts NK cells into I LC1-like cells that are distinct from both steady-state NK cells and ILC1s in uninfected mice, indicating that NK cells can give rise to Eomes– Tbet-dependent ILCs that circulate widely and persist independent of ongoing infection.