P
Placido Borzì
Publications - 15
Citations - 507
Placido Borzì is an academic researcher. The author has contributed to research in topics: Oocyte & Follicular fluid. The author has an hindex of 10, co-authored 13 publications receiving 369 citations.
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Journal ArticleDOI
Molecular characterization of exosomes and their microRNA cargo in human follicular fluid: bioinformatic analysis reveals that exosomal microRNAs control pathways involved in follicular maturation.
Manuela Santonocito,Marilena Vento,Maria Rosa Guglielmino,Rosalia Battaglia,Jessica Wahlgren,Marco Ragusa,Davide Barbagallo,Placido Borzì,Simona Rizzari,Marco Maugeri,Paolo Scollo,Carla Tatone,Hadi Valadi,Michele Purrello,Cinzia Di Pietro +14 more
TL;DR: This study identified a series of exosomal microRNAs that are highly represented in human FF and are involved in follicular maturation and could represent noninvasive biomarkers of oocyte quality in assisted reproductive technology.
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Identification of extracellular vesicles and characterization of miRNA expression profiles in human blastocoel fluid
Rosalia Battaglia,Simone Palini,Marilena Vento,A. La Ferlita,M. J. Lo Faro,Ettore Caroppo,Placido Borzì,Luca Falzone,Davide Barbagallo,Maria Alessandra Ragusa,Marina Scalia,Giuseppe D’Amato,Paolo Scollo,Paolo Musumeci,Michele Purrello,E. Gravotta,C. Di Pietro +16 more
TL;DR: 91 microRNAs, expressed at different levels, able to regulate critical signaling pathways controlling embryo development, such as pluripotency, cell reprogramming, epigenetic modifications, intercellular communication, cell adhesion and cell fate are found.
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MicroRNAs Are Stored in Human MII Oocyte and Their Expression Profile Changes in Reproductive Aging
Rosalia Battaglia,Maria Elena Vento,Marco Ragusa,Davide Barbagallo,Alessandro La Ferlita,Giovanna Di Emidio,Placido Borzì,Paolo Giovanni Artini,Paolo Scollo,Carla Tatone,Michele Purrello,Cinzia Di Pietro +11 more
TL;DR: It is proposed that oocyte miRNAs perform an important regulatory function in human female germ cells, and their altered regulation could explain the changes occurring in oocyte aging.
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TAp73 is downregulated in oocytes from women of advanced reproductive age
Maria Rosa Guglielmino,Manuela Santonocito,Marilena Vento,Marco Ragusa,Davide Barbagallo,Placido Borzì,Ida Casciano,Barbara Banelli,Ottavia Barbieri,Simonetta Astigiano,Paolo Scollo,Massimo Romani,Michele Purrello,Cinzia Di Pietro +13 more
TL;DR: TAp73 down regulation in oocytes from women of advanced reproductive age could explain both the reduction of fertility and the increase of newborns with chromosomal abnormalities.
Journal ArticleDOI
Molecular profiling of human oocytes after vitrification strongly suggests that they are biologically comparable with freshly isolated gametes
Cinzia Di Pietro,Marilena Vento,Maria Rosa Guglielmino,Placido Borzì,Manuela Santonocito,Marco Ragusa,Davide Barbagallo,Laura R Duro,Alessandra Majorana,Adele De Palma,M. R. Garofalo,Elisa Minutolo,Paolo Scollo,Michele Purrello +13 more
TL;DR: The comparison of the molecular profiles demonstrated that the vitrification protocol does not alter the biomolecular quality of oocytes, and this cryopreservation technique might be helpful in preserving women's fertility.