P
Pontus Orning
Researcher at University of Massachusetts Medical School
Publications - 9
Citations - 1049
Pontus Orning is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Pyroptosis & Necroptosis. The author has an hindex of 6, co-authored 9 publications receiving 453 citations. Previous affiliations of Pontus Orning include Norwegian University of Science and Technology.
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Journal ArticleDOI
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
Pontus Orning,Pontus Orning,Dan Weng,Dan Weng,Kristian K. Starheim,Kristian K. Starheim,Dmitry Ratner,Zachary Best,Bettina L. Lee,Alexandria Brooks,Shiyu Xia,Hao Wu,Michelle A. Kelliher,Scott B. Berger,Peter J. Gough,John Bertin,Megan K. Proulx,Jon D. Goguen,Nobuhiko Kayagaki,Katherine A. Fitzgerald,Katherine A. Fitzgerald,Egil Lien,Egil Lien +22 more
TL;DR: Caspase-8 acts as a regulator of GSDMD-driven cell death and contributes to the NLRP3 inflammasome–dependent release of interleukin-1 β (IL-1β) and IL-18, establishing the importance of TAK1 and IKK activity in the control of G SDMD cleavage and cytotoxicity.
Journal ArticleDOI
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation
Venkat Giri Magupalli,Venkat Giri Magupalli,Roberto Negro,Roberto Negro,Yuzi Tian,Yuzi Tian,Arthur V. Hauenstein,Arthur V. Hauenstein,Giuseppe Di Caprio,Giuseppe Di Caprio,Wesley Skillern,Qiufang Deng,Qiufang Deng,Pontus Orning,Pontus Orning,Hasan B. Alam,Zoltan Maliga,Humayun Sharif,Humayun Sharif,Jun Jacob Hu,Jun Jacob Hu,Charles L. Evavold,Jonathan C. Kagan,Florian I. Schmidt,Katherine A. Fitzgerald,Katherine A. Fitzgerald,Tomas Kirchhausen,Tomas Kirchhausen,Yongqing Li,Hao Wu,Hao Wu +30 more
TL;DR: It is found that NLRP3 and pyrin inflammasomes are assembled at the centrosome, also known as the microtubule-organizing center (MTOC), of each cell, which serves as the major site for caspase-1 activation and IL-1β conversion.
Journal ArticleDOI
Gasdermins and their role in immunity and inflammation.
Pontus Orning,Pontus Orning,Egil Lien,Egil Lien,Katherine A. Fitzgerald,Katherine A. Fitzgerald +5 more
TL;DR: This review discusses gasdermin D and its role in disease and shows that it is crucial for optimal defense against microbial infection.
Journal ArticleDOI
Multiple roles of caspase-8 in cell death, inflammation, and innate immunity
TL;DR: The involvement of caspase‐8 in cell death and inflammation is discussed and its role in innate immune responses and in the relationship between different forms of cell death is highlighted.
Journal ArticleDOI
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis
Matija Zelic,Fabrizio Pontarelli,Lisa Woodworth,Cheng Zhu,Amy Mahan,Yi Ren,Michael LaMorte,Ross C. Gruber,Aislinn Keane,Pequita Loring,Lilu Guo,Tai-he Xia,Boyao Zhang,Pontus Orning,Egil Lien,Egil Lien,Alexei Degterev,Timothy R. Hammond,Dimitry Ofengeim +18 more
TL;DR: In this article, the role of glial RIPK1 kinase activity in mediating MS pathogenesis was investigated, and it was shown that RIPK 1 levels correlate with MS disease progression.