C
Charles L. Evavold
Researcher at Boston Children's Hospital
Publications - 20
Citations - 1694
Charles L. Evavold is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Inflammasome & Pyroptosis. The author has an hindex of 9, co-authored 13 publications receiving 979 citations. Previous affiliations of Charles L. Evavold include Harvard University & Centers for Disease Control and Prevention.
Papers
More filters
Journal ArticleDOI
The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.
Charles L. Evavold,Jianbin Ruan,Yunhao Tan,Shiyu Xia,Hao Wu,Jonathan C. Kagan,Jonathan C. Kagan +6 more
TL;DR: It is reported that the pyroptosis regulator gasdermin D (GSDMD) was necessary for IL‐1 secretion from living macrophages that have been exposed to inflammasome activators, such as bacteria and their products or host‐derived oxidized lipids.
Journal ArticleDOI
SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions.
Ferdinando Pucci,Christopher Garris,Charles P. Lai,Andita Newton,Christina Pfirschke,Camilla Engblom,David Alvarez,Melissa M. Sprachman,Charles L. Evavold,Angela Magnuson,Ulrich H. von Andrian,Katharina Glatz,Xandra O. Breakefield,Thorsten R. Mempel,Ralph Weissleder,Mikael J. Pittet +15 more
TL;DR: Track melanoma-derived vesicles at organismal, cellular, and molecular scales to show that endogenous tEVs efficiently disseminate via lymphatics and preferentially bind subcapsular sinus (SCS) CD169+ macrophages in tumor-draining lymph nodes (tdLNs) in mice and humans.
Journal ArticleDOI
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation
Venkat Giri Magupalli,Venkat Giri Magupalli,Roberto Negro,Roberto Negro,Yuzi Tian,Yuzi Tian,Arthur V. Hauenstein,Arthur V. Hauenstein,Giuseppe Di Caprio,Giuseppe Di Caprio,Wesley Skillern,Qiufang Deng,Qiufang Deng,Pontus Orning,Pontus Orning,Hasan B. Alam,Zoltan Maliga,Humayun Sharif,Humayun Sharif,Jun Jacob Hu,Jun Jacob Hu,Charles L. Evavold,Jonathan C. Kagan,Florian I. Schmidt,Katherine A. Fitzgerald,Katherine A. Fitzgerald,Tomas Kirchhausen,Tomas Kirchhausen,Yongqing Li,Hao Wu,Hao Wu +30 more
TL;DR: It is found that NLRP3 and pyrin inflammasomes are assembled at the centrosome, also known as the microtubule-organizing center (MTOC), of each cell, which serves as the major site for caspase-1 activation and IL-1β conversion.
Journal ArticleDOI
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway.
Charles L. Evavold,Iva Hafner-Bratkovič,Pascal Devant,Jasmin M. D’Andrea,Jasmin M. D’Andrea,Elsy M. Ngwa,Elvira Boršić,John G. Doench,Martin W. LaFleur,Martin W. LaFleur,Arlene H. Sharpe,Arlene H. Sharpe,Arlene H. Sharpe,Jay R. Thiagarajah,Jonathan C. Kagan +14 more
TL;DR: In this article, a forward genetic screen was performed to identify the Ragulator-Rag complex as being necessary for GSDMD pore formation and pyroptosis in macrophages.
Journal ArticleDOI
How Inflammasomes Inform Adaptive Immunity.
TL;DR: Evidence for inflammasome-mediated instruction and contextualization of infectious and sterile agents to the adaptive immune system is discussed.