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Bettina L. Lee
Researcher at Genentech
Publications - 11
Citations - 3715
Bettina L. Lee is an academic researcher from Genentech. The author has contributed to research in topics: Inflammasome & Pyroptosis. The author has an hindex of 9, co-authored 10 publications receiving 2198 citations.
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Journal ArticleDOI
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nobuhiko Kayagaki,Irma B. Stowe,Bettina L. Lee,Karen O'Rourke,Keith R. Anderson,Søren Warming,Trinna L. Cuellar,Benjamin Haley,Merone Roose-Girma,Qui T. Phung,Peter Liu,Jennie R. Lill,Hong Li,Jiansheng Wu,Sarah K. Kummerfeld,Juan Zhang,Wyne P. Lee,Scott J. Snipas,Guy S. Salvesen,Lucy X. Morris,Linda Fitzgerald,Yafei Zhang,Edward M. Bertram,Christopher C. Goodnow,Christopher C. Goodnow,Christopher C. Goodnow,Vishva M. Dixit +26 more
TL;DR: It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.
Journal ArticleDOI
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
Pontus Orning,Pontus Orning,Dan Weng,Dan Weng,Kristian K. Starheim,Kristian K. Starheim,Dmitry Ratner,Zachary Best,Bettina L. Lee,Alexandria Brooks,Shiyu Xia,Hao Wu,Michelle A. Kelliher,Scott B. Berger,Peter J. Gough,John Bertin,Megan K. Proulx,Jon D. Goguen,Nobuhiko Kayagaki,Katherine A. Fitzgerald,Katherine A. Fitzgerald,Egil Lien,Egil Lien +22 more
TL;DR: Caspase-8 acts as a regulator of GSDMD-driven cell death and contributes to the NLRP3 inflammasome–dependent release of interleukin-1 β (IL-1β) and IL-18, establishing the importance of TAK1 and IKK activity in the control of G SDMD cleavage and cytotoxicity.
Journal ArticleDOI
NINJ1 mediates plasma membrane rupture during lytic cell death
Nobuhiko Kayagaki,Opher S. Kornfeld,Bettina L. Lee,Irma B. Stowe,Karen O'Rourke,Qingling Li,Wendy Sandoval,Donghong Yan,Jing Kang,Min Xu,Juan Zhang,Wyne P. Lee,Brent S. McKenzie,Gözde Ulas,Jian Payandeh,Merone Roose-Girma,Zora Modrusan,Rohit Reja,Meredith Sagolla,Joshua D. Webster,Vicky Cho,T. Daniel Andrews,Lucy X. Morris,Lisa A. Miosge,Christopher C. Goodnow,Christopher C. Goodnow,Edward M. Bertram,Vishva M. Dixit +27 more
TL;DR: In this article, the authors showed that the cell-surface NINJ1 protein, which contains two transmembrane regions, has an essential role in the induction of PMR.
Journal ArticleDOI
IRF2 transcriptionally induces GSDMD expression for pyroptosis.
Nobuhiko Kayagaki,Bettina L. Lee,Irma B. Stowe,Opher S. Kornfeld,Karen O'Rourke,Kathleen M. Mirrashidi,Benjamin Haley,Colin K. Watanabe,Merone Roose-Girma,Zora Modrusan,Sarah K. Kummerfeld,Rohit Reja,Yafei Zhang,Vicky Cho,T. Daniel Andrews,Lucy X. Morris,Christopher C. Goodnow,Christopher C. Goodnow,Edward M. Bertram,Vishva M. Dixit +19 more
TL;DR: It is shown that IRF2, a member of the interferon regulatory factor (IRF) family of transcription factors, was essential for the transcriptional activation of GSDMD, a critical mediator of inflammatory pathologies.
Journal ArticleDOI
Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation.
Bettina L. Lee,Irma B. Stowe,Aaron Gupta,Opher S. Kornfeld,Merone Roose-Girma,Keith R. Anderson,Søren Warming,Juan Zhang,Wyne P. Lee,Nobuhiko Kayagaki +9 more
TL;DR: Genetic evidence is provided to show that caspase-11 auto-cleavage at the inter-subunit linker is essential for optimal catalytic activity and subsequent proteolytic cleavage of GSDMD.