P
Poonam Gera
Researcher at Cancer Research Institute
Publications - 23
Citations - 578
Poonam Gera is an academic researcher from Cancer Research Institute. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 8, co-authored 18 publications receiving 392 citations.
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Journal ArticleDOI
Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups
Arindam Maitra,Nidhan K. Biswas,Kishore Amin,Pradnya Kowtal,Shantanu Kumar,S. K. Das,Rajiv Sarin,Partha P. Majumder,Indranil Bagchi,Bijan B. Bairagya,Analabha Basu,Maharaj K. Bhan,Pankaj Chaturvedi,D. Das,Anil K. D'Cruz,Rudra Sankar Dhar,Debasmita Dutta,Debdutta Ganguli,Poonam Gera,Tejpal Gupta,Sanchita Mahapatra,M. H. K. Mujawar,Souvik Mukherjee,Sudhir Nair,Santosh Nikam,M. Nobre,Asawari Patil,Santosini Patra,M. Rama-Gowtham,T. S. V. C. Rao,Biman Kanti Roy,B. Roychowdhury,D. Sarkar,S. Sarkar,Neeta Sarkar-Roy,D. Sutradhar +35 more
TL;DR: Molecular subtypes with distinctive mutational profiles such as patients predominantly harbouring mutations in CASP8 with or without mutations in FAT1 are revealed, and the mean duration of disease-free survival is significantly elevated in some molecular subgroups.
Journal ArticleDOI
Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer.
Nazia Chaudhary,Nazia Chaudhary,Bhagya Shree Choudhary,Bhagya Shree Choudhary,Sanket Shah,Nileema Khapare,Nehanjali Dwivedi,Anagha Gaikwad,Neha Joshi,Jinsy Raichanna,Srikanta Basu,Murari Gurjar,P. K. Smitha,Avanish Saklani,Poonam Gera,Mukta Ramadwar,Prachi Patil,Rahul Thorat,Vikram Gota,Sujan K. Dhar,Sanjay Gupta,Manjula Das,Sorab N. Dalal,Sorab N. Dalal +23 more
TL;DR: In this article, a siderophore binding protein, Lipocalin 2, was shown to lead to resistance to 5fluorouracil in colon cancer cell lines in vitro and in vivo by inhibiting ferroptosis.
Journal ArticleDOI
Raman spectroscopy and cytopathology of oral exfoliated cells for oral cancer diagnosis
Aditi Sahu,Sneha Tawde,Venkatesh Pai,Poonam Gera,Pankaj Chaturvedi,Sudhir Nair,C. Murali Krishna +6 more
TL;DR: A large-scale validation study needs to be undertaken for evaluating the utility of Raman oral exfoliative cytology for screening of oral cancers using the patient-wise approach.
Journal ArticleDOI
Elevated HDAC activity and altered histone phospho-acetylation confer acquired radio-resistant phenotype to breast cancer cells
Asmita Sharda,Mudasir Rashid,Sanket Shah,Ajit Sharma,Saurav Raj Singh,Poonam Gera,Murali Krishna Chilkapati,Murali Krishna Chilkapati,Sanjay Gupta +8 more
TL;DR: The study revealed that an imbalance of HAT and HDAC activities led to the loss of site-specific histone acetylation and chromatin compaction as breast cancer cells acquired radio-resistance.
Journal ArticleDOI
ERBB2 and KRAS alterations mediate response to EGFR inhibitors in early stage gallbladder cancer
Prajish Iyer,Shailesh V. Shrikhande,Malika Ranjan,Asim Joshi,Nilesh Gardi,Ratnam Prasad,Bhasker Dharavath,Rahul Thorat,Sameer Salunkhe,Bikram Sahoo,Pratik Chandrani,Hitesh Kore,Bhabani Mohanty,Vikram Chaudhari,Anuradha Choughule,Dhananjay Kawle,Pradip Chaudhari,Arvind Ingle,Shripad Banavali,Poonam Gera,Mukta Ramadwar,Kumar Prabhash,Savio George Barreto,Shilpee Dutt,Amit Dutt +24 more
TL;DR: Overall, besides implicating ERBB2 as an important therapeutic target under neo‐adjuvant or adjuvant settings, this work presents the first evidence that the presence of KRAS mutations may preclude gallbladder cancer patients to respond to anti‐ EGFR treatment, similar to a clinical algorithm commonly practiced to opt for anti‐EGFR treatment in colorectal cancer.