R
Rajat Varma
Researcher at National Institutes of Health
Publications - 41
Citations - 6746
Rajat Varma is an academic researcher from National Institutes of Health. The author has contributed to research in topics: T-cell receptor & Immunological synapse. The author has an hindex of 23, co-authored 40 publications receiving 6377 citations. Previous affiliations of Rajat Varma include Tata Institute of Fundamental Research & New York University.
Papers
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Journal ArticleDOI
GPI-anchored proteins are organized in submicron domains at the cell surface
Rajat Varma,Satyajit Mayor +1 more
TL;DR: The results indicate that lipid-linked proteins are organized in cholesterol-dependent submicron-sized domains, which are likely to be less than 70 nm in diameter and are disrupted by removal of cellular cholesterol.
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Nanoscale Organization of Multiple GPI-Anchored Proteins in Living Cell Membranes
Pranav Sharma,Rajat Varma,R. C. Sarasij,Ira,Karine Gousset,Guruswamy Krishnamoorthy,Madan Rao,Madan Rao,Satyajit Mayor +8 more
TL;DR: The size of lipid-dependent organization of GPI-APs in live cells is investigated using homo and hetero-FRET-based experiments and an analysis of the statistical distribution of the clusters suggest a mechanism for functional lipid- dependent clustering of G PI- APs.
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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.
TL;DR: It is proposed that T CR signaling is sustained by stabilized microclusters and is terminated in the cSMAC, a structure from which TCR are sorted for degradation, and a role for F-actin in TCR signaling beyond microcluster formation is revealed.
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Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling.
TL;DR: T cell receptor (TCR) microclusters form within seconds of T cell contact with supported planar bilayers containing intercellular adhesion molecule-1 and agonist major histocompatibility complex (MHC)-peptide complexes, and elevation of cytoplasmic Ca2+ is observed within seconds after the first detectable micro-clusters as mentioned in this paper.
Journal ArticleDOI
The immunological synapse balances T cell receptor signaling and degradation.
Kyeong-Hee Lee,Kyeong-Hee Lee,Aaron R. Dinner,Chun Tu,Gabriele Campi,Subhadip Raychaudhuri,Rajat Varma,Tasha N. Sims,W. Richard Burack,Hui Wu,Julia Wang,Osami Kanagawa,Mary A. Markiewicz,Paul M. Allen,Michael L. Dustin,Arup K. Chakraborty,Arup K. Chakraborty,Andrey S. Shaw +17 more
TL;DR: In vitro and in silico experiments are used to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.