Tony Ng

TL;DR: This work provides a mechanism for the coordinate repression of let-7 miRNAs observed in a subset of human cancers, and associates activation of LIN28 and LIN28B with poor clinical prognosis.

TL;DR: It is established that YB-1 levels are elevated in invasive breast cancer cells and correlate with reduced expression of E-cadherin and poor patient survival, likely acting together to promote metastatic spread.

TL;DR: It is shown that a frequently occurring SMO alteration encoding p.Leu412Phe is an activating mutation and that its effect on Hedgehog-pathway activity can be inhibited by arsenic trioxide (ATO), an anti-leukemia drug approved by the US Food and Drug Administration that is currently in clinical trials for its Hedge Hog-inhibitory activity.

TL;DR: High-level nuclear β-catenin staining serves as a useful diagnostic tool, as it is specific to a small subset of mesenchymal tumors.

TL;DR: YB-1, which is upregulated in human sarcomas, controls the availability of the stress granule nucleator G3BP1 and thereby controls stress granules assembly.